Alex Avdeef
Overview
Explore the profile of Alex Avdeef including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
75
Citations
1295
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Bergstrom C, Avdeef A
ADMET DMPK
. 2022 Mar;
7(2):88-105.
PMID: 35350542
Several key topics in solubility measurement and interpretation are briefly summarized and illustrated with case studies drawing on published solubility determinations as a function of pH. Featured are examples of...
12.
Avdeef A, Kansy M
ADMET DMPK
. 2022 Mar;
8(3):180-206.
PMID: 35300304
The aim of the study was to explore to what extent small molecules (mostly from the Rule of 5 chemical space) can be used to predict the intrinsic aqueous solubility,...
13.
Avdeef A
ADMET DMPK
. 2022 Mar;
9(1):69-74.
PMID: 35299878
The prediction of solubility of drugs usually calls on the use of several open-source/commercially-available computer programs in the various calculation steps. Popular statistics to indicate the strength of the prediction...
14.
Avdeef A
ADMET DMPK
. 2022 Mar;
8(1):29-77.
PMID: 35299775
The accurate prediction of solubility of drugs is still problematic. It was thought for a long time that shortfalls had been due the lack of high-quality solubility data from the...
15.
Avdeef A, Kansy M
J Solution Chem
. 2022 Feb;
51(9):1020-1055.
PMID: 35153342
This study applies the 'Flexible-Acceptor' variant of the General Solubility Equation, GSE(), to the prediction of the aqueous intrinsic solubility, log , of FDA recently-approved (2016-2020) 'small-molecule' new molecular entities...
16.
Miranda C, Ruiz-Picazo A, Pomares P, Gonzalez-Alvarez I, Bermejo M, Gonzalez-Alvarez M, et al.
Pharmaceutics
. 2022 Jan;
14(1).
PMID: 35057075
The main aim of this work is the biopharmaceutical characterization of a new hybrid benzodiazepine-dihydropyridine derivative, JM-20, derived with potent anti-ischemic and neuroprotective effects. In this study, the pa and...
17.
Markovic O, Patel N, Serajuddin A, Avdeef A, Verbic T
Mol Pharm
. 2022 Jan;
19(2):710-719.
PMID: 35050628
The solubility of a model basic drug, nortriptyline (Nor), was investigated as a function of pH in phosphate and/or a chloride-containing aqueous suspension using experimental practices recommended in the previously...
18.
Avdeef A, Sugano K
J Pharm Sci
. 2021 Dec;
111(1):225-246.
PMID: 34863819
A multiphasic mass action equilibrium model was used to study the phase properties near the critical pH ('pH') in an acid-base transformation of a solid drug salt into its corresponding...
19.
Uekusa T, Avdeef A, Sugano K
Eur J Pharm Sci
. 2021 Oct;
168:106037.
PMID: 34637897
The purpose of the present study was to investigate the suitability of equilibrium slurry pH (pH) as a surrogate of solid surface pH during drug dissolution (pH). A comprehensive calculation...
20.
Avdeef A
Mol Pharm
. 2021 Jun;
18(7):2724-2743.
PMID: 34142831
A multiphasic mass action equilibrium model is used to show that the critical pH in the acid-base disproportionation of a solid salt into its corresponding solid free-base form in aqueous...