Alex Avdeef
Overview
Explore the profile of Alex Avdeef including associated specialties, affiliations and a list of published articles.
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Articles
75
Citations
1295
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Recent Articles
1.
Topalovic I, Markovic O, Pesic M, Kathawala M, Kuentz M, Avdeef A, et al.
Pharmaceutics
. 2025 Jan;
16(12.
PMID: 39771524
Background/objectives: Clofazimine (CFZ) is a Biopharmaceutics Classification System (BCS) II drug introduced in the US market in 1986 for the treatment of leprosy. However, CFZ was later withdrawn from the...
2.
Avdeef A, Serajuddin A, Kandagatla H
Mol Pharm
. 2025 Jan;
22(2):895-905.
PMID: 39754517
Although glycine is the simplest of the amino acids, its solution and solid-state properties are far from straightforward. The aqueous solubility of glycine plays an important role in various applications,...
3.
Syed M, Kandagatla H, Avdeef A, Serajuddin A
Int J Pharm
. 2024 Aug;
663:124548.
PMID: 39098746
Improvement in drug solubility is a major challenge for developing pharmaceutical products. It was demonstrated earlier that aqueous solubilities of weakly basic drugs could be increased greatly by interaction with...
4.
Zoller L, Avdeef A, Karlsson E, Borde A, Carlert S, Saal C, et al.
Eur J Pharm Sci
. 2023 Dec;
193:106684.
PMID: 38154507
Background: Pharmaceutical salts of poorly soluble drugs typically dissolve faster than their corresponding free acid or base, resulting in supersaturation under some circumstances. The key questions relevant to drug bioavailability...
5.
Avdeef A
ADMET DMPK
. 2023 Oct;
11(3):419-432.
PMID: 37829325
Background And Purpose: The widely-used and practically insoluble diprotic acidic dye, bromothymol blue (BTB), is a neutral molecule in strongly acidic aqueous solutions. The Schill (1964) extensive solubility-pH measurement of...
6.
Avdeef A
ADMET DMPK
. 2023 Oct;
11(3):317-330.
PMID: 37829322
Yalkowsky's General Solubility Equation (GSE), with its three fixed constants, is popular and easy to apply, but is not very accurate for polar, zwitterionic, or flexible molecules. This review examines...
7.
Verbic T, Tam K, Veljkovic D, Serajuddin A, Avdeef A
Mol Pharm
. 2023 Apr;
20(6):3160-3169.
PMID: 37096898
The weakly basic antibiotic and anti-inflammatory drug, clofazimine (CFZ), was first described in 1957. It has been used therapeutically, most notably in the treatment of leprosy. However, the compound is...
8.
9.
Kadar S, Csicsak D, Tozser P, Farkas A, Palla T, Mirzahosseini A, et al.
Pharmaceutics
. 2022 Aug;
14(8).
PMID: 36015261
Creating supersaturating drug delivery systems to overcome the poor aqueous solubility of active ingredients became a frequent choice for formulation scientists. Supersaturation as a solution phenomenon is, however, still challenging...
10.
Avdeef A
ADMET DMPK
. 2022 Mar;
7(3):210-219.
PMID: 35350660
This commentary compares 233 CheqSol intrinsic solubility values (log S) reported in the Wiki-pS database for 145 different druglike molecules to the 838 log S values determined mostly by the...