Alessandra Vaccaro
Overview
Explore the profile of Alessandra Vaccaro including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
160
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Recent Articles
1.
Vaccaro A, Rahal Z, Kadara H, Cascone T
Cancer Discov
. 2025 Feb;
:OF1-OF6.
PMID: 39997992
Immunotherapy has revolutionized the treatment of early-stage non-small cell lung cancer; yet many patients fail to achieve long-lasting benefit, partially because of incomplete or inconsistent biomarker predictions. Integrative multiomics, combining...
2.
Wicher G, Roy A, Vaccaro A, Vemuri K, Ramachandran M, Olofsson T, et al.
Neurooncol Adv
. 2025 Feb;
7(1):vdaf010.
PMID: 39931535
Background: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, characterized by aggressive growth and a dismal prognosis. Interleukin-33 (IL-33) and its receptor ST2 have emerged as...
3.
Vaccaro A, de Alves Pereira B, van de Walle T, Dimberg A
Methods Mol Biol
. 2024 Nov;
2864:21-42.
PMID: 39527215
The central nervous system (CNS) constitutes a tightly regulated milieu, where immune responses are strictly controlled to prevent neurological damage. This poses considerable challenges to the therapeutic management of CNS...
4.
Vaccaro A, van de Walle T, Ramachandran M, Essand M, Dimberg A
Front Immunol
. 2023 Nov;
14:1275378.
PMID: 37954592
Tertiary lymphoid structures (TLS) are lymph node-like aggregates that can form in association with chronic inflammation or cancer. Mature TLS are organized into B and T cell zones, and are...
5.
Ajetunmobi O, Chaturvedi A, Badali H, Vaccaro A, Najvar L, Wormley Jr F, et al.
APMIS
. 2023 Jun;
131(11):613-625.
PMID: 37337909
Candida spp. are opportunistic yeasts capable of forming biofilms, which contribute to resistance, increasing the urgency for new effective antifungal therapies. Repurposing existing drugs could significantly accelerate the development of...
6.
Ramachandran M, Vaccaro A, van de Walle T, Georganaki M, Lugano R, Vemuri K, et al.
Cancer Cell
. 2023 May;
41(6):1134-1151.e10.
PMID: 37172581
Glioblastomas are aggressive brain tumors that are largely immunotherapy resistant. This is associated with immunosuppression and a dysfunctional tumor vasculature, which hinder T cell infiltration. LIGHT/TNFSF14 can induce high endothelial...
7.
Flood P, Fanning A, Woznicki J, Crowley T, Christopher A, Vaccaro A, et al.
Am J Physiol Gastrointest Liver Physiol
. 2022 Sep;
323(5):G439-G460.
PMID: 36165492
DNA sensor pathways can initiate inflammasome, cell death, and type I interferon (IFN) signaling in immune-mediated inflammatory diseases (IMIDs), including type I interferonopathies. We investigated the involvement of these pathways...
8.
van de Walle T, Vaccaro A, Ramachandran M, Pietila I, Essand M, Dimberg A
Front Immunol
. 2021 Sep;
12:724739.
PMID: 34539661
Glioblastoma is the most common and aggressive brain tumor, which is uniformly lethal due to its extreme invasiveness and the absence of curative therapies. Immune checkpoint inhibitors have not yet...
9.
van Hooren L, Vaccaro A, Ramachandran M, Vazaios K, Libard S, van de Walle T, et al.
Nat Commun
. 2021 Jul;
12(1):4127.
PMID: 34226552
Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical development for solid tumors, but are yet to be evaluated for glioma. Here,...
10.
Zhang Y, Cedervall J, Hamidi A, Herre M, Viitaniemi K, DAmico G, et al.
Cancer Res
. 2020 Jun;
80(16):3345-3358.
PMID: 32586981
Platelet-derived growth factor B (PDGFB) plays a crucial role in recruitment of PDGF receptor β-positive pericytes to blood vessels. The endothelium is an essential source of PDGFB in this process....