Aleksandra Nivina
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Explore the profile of Aleksandra Nivina including associated specialties, affiliations and a list of published articles.
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13
Citations
302
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Recent Articles
1.
Nivina A, Herrera Paredes S, Fraser H, Khosla C
Proc Natl Acad Sci U S A
. 2021 Jun;
118(26).
PMID: 34162709
Assembly-line polyketide synthases (PKSs) are large and complex enzymatic machineries with a multimodular architecture, typically encoded in bacterial genomes by biosynthetic gene clusters. Their modularity has led to an astounding...
2.
Escudero J, Nivina A, Kemble H, Loot C, Tenaillon O, Mazel D
Elife
. 2020 Dec;
9.
PMID: 33319743
Molecular examples of evolutionary innovation are scarce and generally involve point mutations. Innovation can occur through larger rearrangements, but here experimental data is extremely limited. Integron integrases innovated from double-strand-...
3.
Nivina A, Grieb M, Loot C, Bikard D, Cury J, Shehata L, et al.
Sci Adv
. 2020 Aug;
6(30):eaay2922.
PMID: 32832653
Recombination systems are widely used as bioengineering tools, but their sites have to be highly similar to a consensus sequence or to each other. To develop a recombination system free...
4.
Nivina A, Yuet K, Hsu J, Khosla C
Chem Rev
. 2019 Dec;
119(24):12524-12547.
PMID: 31838842
Assembly-line polyketide synthases (PKSs) are among the most complex protein machineries known in nature, responsible for the biosynthesis of numerous compounds used in the clinic. Their present-day diversity is the...
5.
Vit C, Loot C, Escudero J, Nivina A, Mazel D
Methods Mol Biol
. 2019 Oct;
2075:189-208.
PMID: 31584164
Integrons are genetic elements involved in bacterial adaptation to the environment. Sedentary chromosomal integrons (SCIs) can stockpile and rearrange a myriad of different functions encoded in gene cassettes. Through their...
6.
Klaus M, DSouza A, Nivina A, Khosla C, Grininger M
ACS Chem Biol
. 2019 Jan;
14(3):426-433.
PMID: 30682239
Engineering of assembly line polyketide synthases (PKSs) to produce novel bioactive compounds has been a goal for over 20 years. The apparent modularity of PKSs has inspired many engineering attempts...
7.
Mukhortava A, Poge M, Grieb M, Nivina A, Loot C, Mazel D, et al.
Nucleic Acids Res
. 2018 Dec;
47(4):1861-1870.
PMID: 30566629
A predominant tool for adaptation in Gram-negative bacteria is the functional genetic platform called integron. Integrons capture and rearrange promoterless gene cassettes in a unique recombination process involving the recognition...
8.
Grieb M, Nivina A, Cheeseman B, Hartmann A, Mazel D, Schlierf M
Nucleic Acids Res
. 2017 Oct;
45(18):10555-10563.
PMID: 28985409
Biologically functional DNA hairpins are found in archaea, prokaryotes and eukaryotes, playing essential roles in various DNA transactions. However, during DNA replication, hairpin formation can stall the polymerase and is...
9.
Escudero J, Nivina A, Cambray G, Lopez-Igual R, Loot C, Mazel D
Biotechnol Bioeng
. 2017 Sep;
115(1):184-191.
PMID: 28898391
Synthetic DNA design needs to harness the many information layers embedded in a DNA string. We previously developed the Evolutionary Landscape Painter (ELP), an algorithm that exploits the degeneracy of...
10.
Loot C, Nivina A, Cury J, Escudero J, Ducos-Galand M, Bikard D, et al.
mBio
. 2017 Mar;
8(2).
PMID: 28351923
Integrons ensure a rapid and "on demand" response to environmental stresses driving bacterial adaptation. They are able to capture, store, and reorder functional gene cassettes due to site-specific recombination catalyzed...