Aleksandra Nita-Lazar
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Explore the profile of Aleksandra Nita-Lazar including associated specialties, affiliations and a list of published articles.
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1049
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Recent Articles
1.
Kim D, Nita-Lazar A
J Proteins Proteom
. 2024 Oct;
15(3):545-559.
PMID: 39380887
Understanding protein-protein interactions (PPIs) is pivotal for deciphering the intricacies of biological processes. Dysregulation of PPIs underlies a spectrum of diseases, including cancer, neurodegenerative disorders, and autoimmune conditions, highlighting the...
2.
Spada S, Rose K, Sette P, OConnor S, Dussupt V, Yerramilli V, et al.
bioRxiv
. 2024 Jun;
PMID: 38903125
Significance Statement: When cellular membranes are dissolved or breached, ESCRT is rapidly deployed to repair membranes to restore the integrity of intracellular compartments. Membrane sealing is ensured by ESCRT-III filaments...
3.
Lehman S, Williamson C, Tucholski T, Ellis N, Bouchard S, Jarnik M, et al.
Cell Rep
. 2024 Apr;
43(4):114033.
PMID: 38568811
Small GTPases of the Ras subfamily are best known for their role as proto-oncoproteins, while their function during microbial infection has remained elusive. Here, we show that Legionella pneumophila hijacks...
4.
Rathore D, Marino M, Issara-Amphorn J, Hwan Yoon S, Manes N, Nita-Lazar A
J Proteome Res
. 2024 Mar;
23(8):3280-3293.
PMID: 38527097
RNA-protein interactions within cellular signaling pathways have significant modulatory effects on RNA binding proteins' (RBPs') effector functions. During the innate immune response, specific RNA-protein interactions have been reported as a...
5.
Bhushan V, Nita-Lazar A
J Proteome Res
. 2024 Mar;
23(8):2700-2722.
PMID: 38451675
The mammalian cell is a complex entity, with membrane-bound and membrane-less organelles playing vital roles in regulating cellular homeostasis. Organellar protein niches drive discrete biological processes and cell functions, thus...
6.
Abidin M, Alpan O, Plassmeyer M, Kozhaya L, Loizou D, Dogan M, et al.
medRxiv
. 2024 Jan;
PMID: 38168423
Objective: Chronic rhinosinusitis (CRS) impacts an estimated 5% to 15% of people worldwide, incurring significant economic healthcare burden. There is a urgent need for the discovery of predictive biomarkers to...
7.
Issara-Amphorn J, Sjoelund V, Smelkinson M, Montalvo S, Hwan Yoon S, Manes N, et al.
Sci Rep
. 2023 Nov;
13(1):19562.
PMID: 37949888
MARCKS (myristoylated alanine-rich C-kinase substrate) is a membrane-associated protein expressed in many cell types, including macrophages. MARCKS is functionally implicated in cell adhesion, phagocytosis, and inflammation. LPS (lipopolysaccharide) triggers inflammation...
8.
Issara-Amphorn J, Sjoelund V, Smelkinson M, Hwan Yoon S, Manes N, Nita-Lazar A
Res Sq
. 2023 Oct;
PMID: 37790394
MARCKS (Myristoylated Alanine-rich C-kinase Substrate) is a membrane protein expressed in many cell types, including macrophages. MARCKS is functionally implicated in cell adhesion, phagocytosis, and inflammation. LPS (lipopolysaccharide) triggers inflammation...
9.
Rochman M, Rochman Y, Caldwell J, Mack L, Besse J, Manes N, et al.
JCI Insight
. 2023 Jul;
8(17).
PMID: 37490338
Eosinophilic esophagitis (EoE) is a chronic gastrointestinal disorder characterized by food antigen-driven eosinophilic inflammation and hyperproliferation of esophageal mucosa. By utilizing a large-scale, proteomic screen of esophageal biopsies, we aimed...
10.
Saisorn W, Phuengmaung P, Issara-Amphorn J, Makjaroen J, Visitchanakun P, Sae-Khow K, et al.
Int J Mol Sci
. 2023 Jun;
24(12).
PMID: 37373287
Despite the known influence of DNA methylation from lipopolysaccharide (LPS) activation, data on the O6-methylguanine-DNA methyltransferase (MGMT, a DNA suicide repair enzyme) in macrophages is still lacking. The transcriptomic profiling...