Aleksandr Shamanaev
Overview
Explore the profile of Aleksandr Shamanaev including associated specialties, affiliations and a list of published articles.
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9
Citations
120
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Recent Articles
1.
Shamanaev A, Ma Y, Ponczek M, Sun M, Cheng Q, Dickeson S, et al.
Blood Adv
. 2025 Jan;
PMID: 39883942
In plasma, the zymogens factor XII (FXII) and prekallikrein reciprocally convert each other to the proteases FXIIa and plasma kallikrein (PKa). PKa cleaves high-molecular-weight kininogen (HK) to release bradykinin, which...
2.
Shamanaev A, Dickeson S, Ivanov I, Litvak M, Sun M, Kumar S, et al.
Front Physiol
. 2023 Jun;
14:1146834.
PMID: 37288434
Patients with the inherited disorder hereditary angioedema (HAE) suffer from episodes of soft tissue swelling due to excessive bradykinin production. In most cases, dysregulation of the plasma kallikrein-kinin system due...
3.
Shamanaev A, Litvak M, Ivanov I, Srivastava P, Sun M, Dickeson S, et al.
Semin Thromb Hemost
. 2023 Jun;
50(7):937-952.
PMID: 37276883
Factor XII (FXII), the zymogen of the protease FXIIa, contributes to pathologic processes such as bradykinin-dependent angioedema and thrombosis through its capacity to convert the homologs prekallikrein and factor XI...
4.
Shamanaev A, Litvak M, Cheng Q, Ponczek M, Dickeson S, Smith S, et al.
J Thromb Haemost
. 2023 Mar;
21(6):1567-1579.
PMID: 36863563
Background: During plasma contact activation, factor XII (FXII) binds to surfaces through its heavy chain and undergoes conversion to the protease FXIIa. FXIIa activates prekallikrein and factor XI (FXI). Recently,...
5.
Litvak M, Shamanaev A, Zalawadiya S, Matafonov A, Kobrin A, Feener E, et al.
J Thromb Haemost
. 2023 Jan;
21(5):1200-1213.
PMID: 36696212
Background: Titanium (Ti) and its alloys are widely used in manufacturing medical devices because of their strength and resistance to corrosion. Although Ti compounds are considered compatible with blood, they...
6.
Shamanaev A, Litvak M, Gailani D
Curr Opin Hematol
. 2022 Aug;
29(5):233-243.
PMID: 35916558
Purpose Of Review: Factor XII (FXII), the precursor of the protease FXIIa, contributes to pathologic processes including angioedema and thrombosis. Here, we review recent work on structure-function relationships for FXII...
7.
Shamanaev A, Ivanov I, Sun M, Litvak M, Srivastava P, Mohammed B, et al.
Blood Adv
. 2022 Jan;
6(10):3142-3154.
PMID: 35086137
Factor XII (FXII) is the zymogen of a plasma protease (FXIIa) that contributes to bradykinin generation by converting prekallikrein to the protease plasma kallikrein (PKa). FXII conversion to FXIIa by...
8.
Ponczek M, Shamanaev A, LaPlace A, Dickeson S, Srivastava P, Sun M, et al.
Blood Adv
. 2020 Dec;
4(24):6135-6147.
PMID: 33351111
Factor XI (FXI) is the zymogen of a plasma protease (FXIa) that contributes to hemostasis by activating factor IX (FIX). In the original cascade model of coagulation, FXI is converted...
9.
Shamanaev A, Emsley J, Gailani D
J Thromb Haemost
. 2020 Oct;
19(2):330-341.
PMID: 33107140
Contact activation is triggered when blood is exposed to compounds or "surfaces" that promote conversion of the plasma zymogens factor XII (FXII) and prekallikrein to the active proteases FXIIa and...
10.
Silasi R, Keshari R, Lupu C, Van Rensburg W, Chaaban H, Regmi G, et al.
Blood Adv
. 2019 Feb;
3(4):658-669.
PMID: 30808684
infections can produce systemic bacteremia and inflammation in humans, which may progress to severe sepsis or septic shock, even with appropriate antibiotic treatment. Sepsis may be associated with disseminated intravascular...