Aleksandr Pankov
Overview
Explore the profile of Aleksandr Pankov including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
439
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0
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Recent Articles
1.
Chen C, Khanna V, Kummar S, Abdul-Karim R, Sommerhalder D, Tolcher A, et al.
Cancer Res Commun
. 2024 Aug;
4(9):2415-2426.
PMID: 39177285
Purpose: In preclinical models, glucocorticoid receptor (GR) signaling drives resistance to taxane chemotherapy in multiple solid tumors via upregulation of antiapoptotic pathways. ORIC-101 is a potent and selective GR antagonist...
2.
Abida W, Hahn A, Shore N, Agarwal N, Sieber P, Smith M, et al.
Clin Cancer Res
. 2024 Jan;
30(6):1111-1120.
PMID: 38226958
Purpose: Increased glucocorticoid receptor (GR) signaling is a proposed compensatory mechanism of resistance to androgen receptor (AR) inhibition in metastatic castration-resistant prostate cancer (mCRPC). ORIC-101 is a potent and selective...
3.
Dorso M, Patel P, Pankov A, Boyer J, Soni R, Del Priore I, et al.
Cancer Res Commun
. 2023 Sep;
3(9):1788-1799.
PMID: 37691854
Significance: NSCLC is the leading cause of cancer deaths worldwide. There is a need to identify novel druggable dependencies. We identify a subset of NSCLCs dependent on FOXA1-GR and sensitive...
4.
Mazor T, Chesnelong C, Pankov A, Jalbert L, Hong C, Hayes J, et al.
Proc Natl Acad Sci U S A
. 2017 Sep;
114(40):10743-10748.
PMID: 28916733
mutation is the earliest genetic alteration in low-grade gliomas (LGGs), but its role in tumor recurrence is unclear. Mutant IDH1 drives overproduction of the oncometabolite d-2-hydroxyglutarate (2HG) and a CpG...
5.
Ye J, Jin H, Pankov A, Song J, Blelloch R
RNA
. 2017 May;
23(8):1270-1284.
PMID: 28487382
While years of investigation have elucidated many aspects of embryonic stem cell (ESC) regulation, the contributions of post-transcriptional and translational mechanisms to the pluripotency network remain largely unexplored. In particular,...
6.
Binney R, Pankov A, Marx G, He X, McKenna F, Staffaroni A, et al.
Brain Behav
. 2017 Apr;
7(4):e00675.
PMID: 28413716
Introduction: Longitudinal imaging of neurodegenerative disorders is a potentially powerful biomarker for use in clinical trials. In Alzheimer's disease, studies have demonstrated that empirically derived regions of interest (ROIs) can...
7.
Pankov A, Binney R, Staffaroni A, Kornak J, Attygalle S, Schuff N, et al.
Neuroimage Clin
. 2016 Aug;
12:332-40.
PMID: 27547726
Current research is investigating the potential utility of longitudinal measurement of brain structure as a marker of drug effect in clinical trials for neurodegenerative disease. Recent studies in Alzheimer's disease...
8.
Viswanath P, Najac C, Izquierdo-Garcia J, Pankov A, Hong C, Eriksson P, et al.
Oncotarget
. 2016 May;
7(23):34942-55.
PMID: 27144334
Mutations in isocitrate dehydrogenase 1 (IDH1) are characteristic of low-grade gliomas. We recently showed that mutant IDH1 cells reprogram cellular metabolism by down-regulating pyruvate dehydrogenase (PDH) activity. Reduced pyruvate metabolism...
9.
Mazor T, Pankov A, Song J, Costello J
Cancer Cell
. 2016 Apr;
29(4):440-451.
PMID: 27070699
Investigation into intratumoral heterogeneity (ITH) of the epigenome is in a formative stage. The patterns of tumor evolution inferred from epigenetic ITH and genetic ITH are remarkably similar, suggesting widespread...
10.
Olow A, Chen Z, Niedner R, Wolf D, Yau C, Pankov A, et al.
Cancer Res
. 2016 Feb;
76(7):1733-45.
PMID: 26921330
Kinase inhibitors are used widely to treat various cancers, but adaptive reprogramming of kinase cascades and activation of feedback loop mechanisms often contribute to therapeutic resistance. Determining comprehensive, accurate maps...