Alejandro Sarrion-Perdigones
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Explore the profile of Alejandro Sarrion-Perdigones including associated specialties, affiliations and a list of published articles.
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22
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689
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Recent Articles
1.
Venken K, Matinyan N, Gonzalez Y, Sarrion-Perdigones A, Dierick H
Curr Protoc
. 2023 Feb;
3(2):e653.
PMID: 36757602
We recently described a drug-based selectable and counterselectable genetic platform for the animal model system Drosophila melanogaster, consisting of four resistance and two sensitivity markers that allow direct selection for,...
2.
Sarrion-Perdigones A, Gonzalez Y, Chang L, Gallego-Flores T, Young D, Venken K
Methods Mol Biol
. 2022 Jul;
2524:433-456.
PMID: 35821491
We recently expanded the commonly used dual luciferase assaying method toward multiplex hextuple luciferase assaying, allowing monitoring the activity of five experimental pathways against one control at the same time....
3.
Sarrion-Perdigones A, Gonzalez Y, Venken K
Methods Mol Biol
. 2022 Jul;
2524:409-432.
PMID: 35821490
Multiplex hextuple luciferase assaying allows monitoring the activity of five experimental pathways against one control at the same time. To perform multiplex hextuple luciferase assaying, six orthogonal luciferase reporter units...
4.
Chmielowiec J, Szlachcic W, Yang D, Scavuzzo M, Wamble K, Sarrion-Perdigones A, et al.
Nat Commun
. 2022 Apr;
13(1):1952.
PMID: 35414140
In vitro derivation of pancreatic β-cells from human pluripotent stem cells holds promise as diabetes treatment. Despite recent progress, efforts to generate physiologically competent β-cells are still hindered by incomplete...
5.
Matinyan N, Karkhanis M, Gonzalez Y, Jain A, Saltzman A, Malovannaya A, et al.
Cell Rep
. 2021 Sep;
36(11):109700.
PMID: 34525356
The power of Drosophila melanogaster as a model system relies on tractable germline genetic manipulations. Despite Drosophila's expansive genetics toolbox, such manipulations are still accomplished one change at a time...
6.
Wang J, Liu H, Bertrand R, Sarrion-Perdigones A, Gonzalez Y, Venken K, et al.
Genet Med
. 2020 Sep;
23(1):59-68.
PMID: 32884132
Purpose: To achieve the ultimate goal of personalized treatment of patients, accurate molecular diagnosis and precise interpretation of the impact of genetic variants on gene function is essential. With sequencing...
7.
Sarrion-Perdigones A, Chang L, Gonzalez Y, Gallego-Flores T, Young D, Venken K
Curr Protoc Mol Biol
. 2020 Jun;
131(1):e122.
PMID: 32539239
Multiplex experimentation that can assay multiple cellular signaling pathways in the same cells requires orthogonal genetically encoded reporters that report over large dynamic ranges. Luciferases are cost-effective, versatile candidates whose...
8.
Sarrion-Perdigones A, Gonzalez Y, Venken K
Curr Protoc Mol Biol
. 2020 Jun;
131(1):e121.
PMID: 32539183
High-throughput cell-based screening assays are valuable tools in the discovery of chemical probes and therapeutic agents. Such assays are designed to examine the effects of small compounds on targets, pathways,...
9.
Kundert P, Sarrion-Perdigones A, Gonzalez Y, Katoh-Kurasawa M, Hirose S, Lehmann P, et al.
Nucleic Acids Res
. 2020 Apr;
48(8):4139-4146.
PMID: 32232356
GoldenBraid is a rapid, modular, and robust cloning system used to assemble and combine genetic elements. Dictyostelium amoebae represent an intriguing synthetic biological chassis with tractable applications in development, chemotaxis,...
10.
Vazquez-Vilar M, Gandia M, Garcia-Carpintero V, Marques E, Sarrion-Perdigones A, Yenush L, et al.
Curr Protoc Mol Biol
. 2020 Mar;
130(1):e116.
PMID: 32150346
Many synthetic biologists have adopted methods based on Type IIS restriction enzymes and Golden Gate technology in their cloning procedures, as these enable the combinatorial assembly of modular elements in...