Alejandro A Pezzulo
Overview
Explore the profile of Alejandro A Pezzulo including associated specialties, affiliations and a list of published articles.
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63
Citations
2793
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Recent Articles
1.
Carmo D, Pezzulo A, Villacreses R, Eisenbeisz M, Anderson R, Dorin S, et al.
Sci Data
. 2025 Mar;
12(1):402.
PMID: 40055348
The field of supervised automated medical imaging segmentation suffers from relatively small datasets with ground truth labels. This is especially true for challenging segmentation problems that target structures with low...
2.
Szachowicz P, Wohlford-Lenane C, Donelson C, Ghimire S, Thurman A, Xue B, et al.
iScience
. 2025 Mar;
28(3):111930.
PMID: 40034849
studies and observational human disease data suggest the complement system contributes to SARS-CoV-2 pathogenesis, although how complement dysregulation develops in severe COVID-19 is unknown. Here, using a mouse-adapted SARS-CoV-2 virus...
3.
Stapleton E, Metwali N, Shlossman M, Wendt L, Pezzulo A, Hamzeh N, et al.
Res Sq
. 2024 Nov;
PMID: 39502781
Background: Sarcoidosis is a multi-system disease frequently affecting the lungs. It is thought to be mediated by gene-environment interaction; for example, epidemiological data show organic aerosol exposure increases risk of...
4.
Romano Ibarra G, Lei L, Yu W, Thurman A, Gansemer N, Meyerholz D, et al.
J Clin Invest
. 2024 Sep;
134(21.
PMID: 39255033
The airway surface liquid (ASL) plays a crucial role in lung defense mechanisms, and its composition and volume are regulated by the airway epithelium. The cystic fibrosis transmembrane conductance regulator...
5.
Abou Alaiwa M, Hilkin B, Price M, Gansemer N, Rector M, Stroik M, et al.
bioRxiv
. 2024 Sep;
PMID: 39229081
Mutations in more than 50 different genes cause primary ciliary dyskinesia (PCD) by disrupting the activity of motile cilia that facilitate mucociliary transport (MCT). Knowledge of PCD has come from...
6.
Ghimire S, Xue B, Li K, Gannon R, Wohlford-Lenane C, Thurman A, et al.
bioRxiv
. 2024 Jul;
PMID: 39005257
Treatments available to prevent progression of virus-induced lung diseases, including coronavirus disease 2019 (COVID-19) are of limited benefit once respiratory failure occurs. The efficacy of approved and emerging cytokine signaling-modulating...
7.
Szachowicz P, Wohlford-Lenane C, Heinen C, Ghimire S, Xue B, Boly T, et al.
bioRxiv
. 2024 Jun;
PMID: 38895461
Evidence from in vitro studies and observational human disease data suggest the complement system plays a significant role in SARS-CoV-2 pathogenesis, although how complement dysregulation develops in patients with severe...
8.
Rehman T, Pezzulo A, Thurman A, Zemans R, Welsh M
JCI Insight
. 2024 Jun;
9(14.
PMID: 38888974
Cystic fibrosis (CF) is a genetic disorder that disrupts CF transmembrane conductance regulator (CFTR) anion channels and impairs airway host defenses. Airway inflammation is ubiquitous in CF, and suppressing it...
9.
Bowen J, Keck K, Baruah S, Nguyen K, Thurman A, Pezzulo A, et al.
J Leukoc Biol
. 2024 Mar;
116(2):409-423.
PMID: 38547428
Asthma affects 25 million Americans, and recent advances in treatment are effective for only a portion of severe asthma patients. TREM-1, an innate receptor that canonically amplifies inflammatory signaling in...
10.
Li K, Verma A, Li P, Ortiz M, Hawkins G, Schnicker N, et al.
J Virol
. 2024 Jan;
98(1):e0151023.
PMID: 38168680
The Coronavirus Disease 2019 (COVID-19) pandemic continues to cause extraordinary loss of life and economic damage. Animal models of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection are needed to better understand...