Aled Phillips
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Explore the profile of Aled Phillips including associated specialties, affiliations and a list of published articles.
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28
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985
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Recent Articles
11.
Simpson R, Wells A, Thomas D, Stephens P, Steadman R, Phillips A
Am J Pathol
. 2010 Jan;
176(3):1215-28.
PMID: 20093489
Fibroblast differentiation into myofibroblasts is a key event during normal wound repair. We have previously demonstrated an age-related defect in this process associated with impaired synthesis of hyaluronan (HA) synthase...
12.
Krupa A, Jenkins R, Luo D, Lewis A, Phillips A, Fraser D
J Am Soc Nephrol
. 2010 Jan;
21(3):438-47.
PMID: 20056746
The role of microRNAs (miRs), which are endogenous RNA oligonucleotides that regulate gene expression, in diabetic nephropathy is unknown. Here, we performed expression profiling of cultured proximal tubular cells (PTCs)...
13.
Simpson R, Meran S, Thomas D, Stephens P, Bowen T, Steadman R, et al.
Am J Pathol
. 2009 Oct;
175(5):1915-28.
PMID: 19808648
We have previously demonstrated that transforming growth factor-beta1 (TGF-beta1)-mediated fibroblast-myofibroblast differentiation is associated with accumulation of a hyaluronan (HA) pericellular coat. The current study demonstrates failure of fibroblast-myofibroblast differentiation associated...
14.
Webber J, Jenkins R, Meran S, Phillips A, Steadman R
Am J Pathol
. 2009 Jun;
175(1):148-60.
PMID: 19541937
Myofibroblasts are contractile cells that are characterized by the expression of alpha-smooth muscle actin and mediate the closure of wounds and the formation of collagen-rich scars. Their presence in organs...
15.
Luo D, Fielding C, Phillips A, Fraser D
Nephrol Dial Transplant
. 2009 May;
24(9):2655-65.
PMID: 19420104
Background: Increased transforming growth factor beta-1 (TGF beta) expression in the kidney is central not only to the pathogenesis of tubulointerstitial fibrosis but also in repair following acute injury. Recent...
16.
Webber J, Meran S, Steadman R, Phillips A
J Biol Chem
. 2009 Feb;
284(14):9083-92.
PMID: 19193641
The differentiation of resident fibroblasts to myofibroblasts is central to wound healing. In the context of organ fibrosis, however, persistence of these myofibroblasts is associated with progressive disease. This study...
17.
Chang C, Hung C, Chen Y, Yen T, Wu M, Yang C, et al.
Nephrol Dial Transplant
. 2007 Nov;
23(4):1126-34.
PMID: 18045816
Background: Transformation growth factor-beta1 (TGF-beta1) inhibits transepithelial sodium transport and suppresses the epithelial sodium channel (ENaC) in many different types of epithelial cells; however, the molecular mechanism of this effect...
18.
Zhang M, Lee C, Luo D, Krupa A, Fraser D, Phillips A
J Biol Chem
. 2007 Jul;
282(39):28639-28647.
PMID: 17623674
Transforming growth factor-beta1 (TGF-beta1)-mediated loss of proximal tubular epithelial cell-cell interaction is regulated in a polarized fashion. The aim of this study was to further explore the polarity of the...
19.
Meran S, Thomas D, Stephens P, Martin J, Bowen T, Phillips A, et al.
J Biol Chem
. 2007 Jul;
282(35):25687-97.
PMID: 17611197
This study aimed to understand the role of the matrix polysaccharide, hyaluronan (HA), in influencing the scarring process by assessing its impact on regulating fibroblast behavior. Donor-matched human oral and...
20.
Phillips A
Chang Gung Med J
. 2007 May;
30(1):2-6.
PMID: 17477023
In PTC, it is clear that TGF-beta1 synthesis may be controlled independently at the levels of transcription and translation. In the context of diabetic nephropathy glucose is a potent stimulus...