Albert T Lam
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Explore the profile of Albert T Lam including associated specialties, affiliations and a list of published articles.
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7
Citations
120
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Recent Articles
1.
Stephens E, Zhang X, Lam A, Li J, Pei H, Louie S, et al.
Chem Commun (Camb)
. 2023 Nov;
59(93):13843-13846.
PMID: 37921487
An NAD featuring an adenosyl 4'-azido functions as a general substrate for poly-ADP-ribose polymerases. Its derived mono- and poly-ADP-ribosylated proteins can be adequately recognized by distinct ADP-ribosylation-specific readers. This molecule...
2.
Zhang X, Lam A, Cheng Q, Courouble V, Strutzenberg T, Li J, et al.
Chem Sci
. 2022 Mar;
13(7):1982-1991.
PMID: 35308855
Among various protein posttranslational modifiers, poly-ADP-ribose polymerase 1 (PARP1) is a key player for regulating numerous cellular processes and events through enzymatic attachments of target proteins with ADP-ribose units donated...
3.
Lam A, Zhang X, Courouble V, Strutzenberg T, Pei H, Stiles B, et al.
ACS Chem Biol
. 2021 Feb;
16(2):389-396.
PMID: 33524253
Protein poly-ADP-ribosylation (PARylation) is a heterogeneous and dynamic post-translational modification regulated by various writers, readers, and erasers. It participates in a variety of biological events and is involved in many...
4.
Park M, Vaikari V, Lam A, Zhang Y, MacKay J, Alachkar H
J Control Release
. 2020 May;
324:317-329.
PMID: 32428520
FLT3 receptor is an important therapeutic target in acute myeloid leukemia due to high incidence of mutations associated with poor clinical outcome. Targeted therapies against the FLT3 receptor, including small-molecule...
5.
Zhang X, Cheng Q, Chen J, Lam A, Lu Y, Dai Z, et al.
Nat Commun
. 2019 Sep;
10(1):4196.
PMID: 31519936
Nicotinamide adenine dinucleotide (NAD)-dependent ADP-ribosylation plays important roles in physiology and pathophysiology. It has been challenging to study this key type of enzymatic post-translational modification in particular for protein poly-ADP-ribosylation...
6.
Chen J, Lam A, Zhang Y
Anal Biochem
. 2017 Dec;
543:132-139.
PMID: 29247608
ADP-ribosyltransferases (ARTs) catalyze reversible additions of mono- and poly-ADP-ribose onto diverse types of proteins by using nicotinamide adenine dinucleotide (NAD) as a cosubstrate. In the human ART superfamily, 14 out...
7.
Bogorad I, Chen C, Theisen M, Wu T, Schlenz A, Lam A, et al.
Proc Natl Acad Sci U S A
. 2014 Oct;
111(45):15928-33.
PMID: 25355907
Methanol is an important intermediate in the utilization of natural gas for synthesizing other feedstock chemicals. Typically, chemical approaches for building C-C bonds from methanol require high temperature and pressure....