Albert Mennone
Overview
Explore the profile of Albert Mennone including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
966
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0
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Recent Articles
1.
Cai S, Ge M, Mennone A, Hoque R, Ouyang X, Boyer J
Cell Mol Gastroenterol Hepatol
. 2019 Dec;
9(4):679-688.
PMID: 31887435
Background & Aims: Inflammation plays an important role in the pathogenesis of cholestatic liver injury, but it is unclear whether the inflammasome is involved and is the objective of this...
2.
Guerra M, Florentino R, Franca A, Lima Filho A, Dos Santos M, Fonseca R, et al.
Gut
. 2019 Jul;
68(9):1676-1687.
PMID: 31315892
Background & Objectives: Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide. Several types of chronic liver disease predispose to HCC, and several different signalling pathways have...
3.
Yu D, Cai S, Mennone A, Vig P, Boyer J
Liver Int
. 2018 Jan;
38(6):1128-1138.
PMID: 29356312
Background & Aims: Cholestatic liver injury is mediated by bile acid-induced inflammatory responses. We hypothesized that superior therapeutic effects might be achieved by combining treatments that reduce the bile acid...
4.
Khamphaya T, Chukijrungroat N, Saengsirisuwan V, Mitchell-Richards K, Robert M, Mennone A, et al.
Hepatology
. 2017 Oct;
67(2):560-574.
PMID: 29023819
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. It may result in several types of liver problems, including impaired liver regeneration (LR), but the mechanism for...
5.
Cai S, Ouyang X, Chen Y, Soroka C, Wang J, Mennone A, et al.
JCI Insight
. 2017 Mar;
2(5):e90780.
PMID: 28289714
Mechanisms of bile acid-induced (BA-induced) liver injury in cholestasis are controversial, limiting development of new therapies. We examined how BAs initiate liver injury using isolated liver cells from humans and...
6.
Xu S, Soroka C, Sun A, Backos D, Mennone A, Suchy F, et al.
PLoS One
. 2016 Jun;
11(6):e0158269.
PMID: 27351185
The heteromeric membrane protein Organic Solute Transporter alpha/beta is the major bile acid efflux transporter in the intestine. Physical association of its alpha and beta subunits is essential for their...
7.
Li M, Mennone A, Soroka C, Hagey L, Ouyang X, Weinman E, et al.
Hepatology
. 2015 Jun;
62(4):1227-36.
PMID: 26108984
Unlabelled: The intercellular adhesion molecule 1 (ICAM-1) is induced in mouse liver after bile duct ligation (BDL) and plays a key role in neutrophil-mediated liver injury in BDL mice. ICAM-1...
8.
Mistry P, Liu J, Sun L, Chuang W, Yuen T, Yang R, et al.
Proc Natl Acad Sci U S A
. 2014 Mar;
111(13):4934-9.
PMID: 24639522
The inherited deficiency of the lysosomal glucocerebrosidase (GBA) due to mutations in the GBA gene results in Gaucher disease (GD). A vast majority of patients present with nonneuronopathic, type 1...
9.
Cai S, Mennone A, Soroka C, Boyer J
J Pharmacol Exp Ther
. 2014 Feb;
349(1):94-8.
PMID: 24492652
Chronic cholestasis results in liver injury and eventually liver failure. Although ursodeoxycholic acid (UDCA) showed limited benefits in primary biliary cirrhosis, there is an urgent need to develop alternative therapy...
10.
Cai S, Mennone A, Soroka C, Boyer J
Am J Physiol Gastrointest Liver Physiol
. 2014 Feb;
306(8):G670-6.
PMID: 24481602
Deficiency of ABCB4 is associated with several forms of cholestasis in humans. Abcb4(-/-) mice also develop cholestasis, but it remains uncertain what role other canalicular transporters play in the development...