Albert H Gough
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Explore the profile of Albert H Gough including associated specialties, affiliations and a list of published articles.
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7
Citations
175
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Recent Articles
1.
Ji B, Xue Y, Xu Y, Liu S, Gough A, Xie X, et al.
ACS Chem Neurosci
. 2021 May;
12(10):1777-1790.
PMID: 33950681
Opioids and benzodiazepines have complex drug-drug interactions (DDIs), which serve as an important source of adverse drug effects. In this work, we predicted the DDI between oxycodone (OXY) and diazepam...
2.
Li X, George S, Vernetti L, Gough A, Taylor D
Lab Chip
. 2018 Aug;
18(17):2614-2631.
PMID: 30063238
The vLAMPS is a human, biomimetic liver MPS, in which the ECM and cell seeding of the intermediate layer prior to assembly, simplifies construction of the model and makes the...
3.
Shun T, Gough A, Sanker S, Hukriede N, Vogt A
Assay Drug Dev Technol
. 2017 Aug;
15(6):257-266.
PMID: 28800244
Zebrafish embryos are a near-ideal animal model for drug discovery because of their high genetic and physiological similarity to mammals, small size, high fecundity, and optical transparency. The latter properties...
4.
Lee-Montiel F, George S, Gough A, Sharma A, Wu J, DeBiasio R, et al.
Exp Biol Med (Maywood)
. 2017 Apr;
242(16):1617-1632.
PMID: 28409533
This article describes our next generation human Liver Acinus MicroPhysiology System (LAMPS). The key demonstration of this study was that Zone 1 and Zone 3 microenvironments can be established by...
5.
Gough A, Chen N, Shun T, Lezon T, Boltz R, Reese C, et al.
PLoS One
. 2014 Jul;
9(7):e102678.
PMID: 25036749
One of the greatest challenges in biomedical research, drug discovery and diagnostics is understanding how seemingly identical cells can respond differently to perturbagens including drugs for disease treatment. Although heterogeneity...
6.
Giuliano K, Gough A, Taylor D, Vernetti L, Johnston P
J Biomol Screen
. 2010 Jul;
15(7):783-97.
PMID: 20639501
The integration of high-content screening (HCS) readers with organ-specific cell models, panels of functional biomarkers, and advanced informatics is a powerful approach to identifying the toxic liabilities of compounds early...
7.
Gough A, Johnston P
Methods Mol Biol
. 2006 Sep;
356:41-61.
PMID: 16988394
High content screening (HCS) platforms integrate fluorescence microscopy with image analysis algorithms and informatics to automate cell analysis. The initial applications of HCS to secondary screening in drug discovery have...