Alan Rolfe
Overview
Explore the profile of Alan Rolfe including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
28
Citations
257
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Rolfe A, Yao S, Nguyen T, Omoto K, Colombo F, Virrankoski M, et al.
ACS Med Chem Lett
. 2020 Jun;
11(6):1305-1309.
PMID: 32551016
Carbamoyl phosphate synthetase 1 (CPS1) is a potential synthetic lethal target in LKB1-deficient nonsmall cell lung cancer, where its overexpression supports the production of pyrimidine synthesis. In other cancer types,...
2.
Yao S, Nguyen T, Rolfe A, Agrawal A, Ke J, Peng S, et al.
Cell Chem Biol
. 2020 Feb;
27(3):259-268.e5.
PMID: 32017919
Carbamoyl phosphate synthetase 1 (CPS1) catalyzes the first step in the ammonia-detoxifying urea cycle, converting ammonia to carbamoyl phosphate under physiologic conditions. In cancer, CPS1 overexpression supports pyrimidine synthesis to...
3.
Nguyen T, Yao S, Wang Y, Rolfe A, Selvaraj A, Darman R, et al.
J Biol Chem
. 2019 Oct;
294(45):16966-16977.
PMID: 31582562
DNMT3A (DNA methyltransferase 3A) is a DNA methyltransferase responsible for establishing CpG methylation patterns within the genome. DNMT3A activity is essential for normal development, and its dysfunction has been linked...
4.
Faisal S, Maity P, Zang Q, Rolfe A, Hanson P
ACS Comb Sci
. 2016 Jun;
18(7):394-8.
PMID: 27300761
The development of new ROMP-derived silica-immobilized heterocyclic phosphate reagents and their application in purification-free protocols is reported. Grafting of norbornenyl norbornenyl-functionalized (Nb-tagged) silica particles with functionalized Nb-tagged heterocyclic phosphate monomers...
5.
Maity P, Faisal S, Rolfe A, Stoianova D, Hanson P
J Org Chem
. 2015 Oct;
80(20):9942-50.
PMID: 26430955
The syntheses of silica-supported oligomeric benzyl phosphates (Si-OBP(n)) and triazole phosphates (Si-OTP(n)) using ring-opening metathesis polymerization (ROMP) for use as efficient alkylating reagents is reported. Ease of synthesis and grafting...
6.
Loh J, Yoon S, Samarakoon T, Rolfe A, Porubsky P, Neuenswander B, et al.
Beilstein J Org Chem
. 2012 Sep;
8:1293-302.
PMID: 23019462
The efficient synthesis of an 80-member library of unique benzoxathiazocine 1,1-dioxides by a microwave-assisted, intermolecular nucleophilic aromatic substitution (S(N)Ar) diversification pathway is reported. Eight benzofused sultam cores were generated by...
7.
Faisal S, Ullah F, Maity P, Rolfe A, Samarakoon T, Porubsky P, et al.
ACS Comb Sci
. 2012 Mar;
14(4):268-72.
PMID: 22384820
A combination of MACOS scale-out and ROMP-derived oligomeric triazole phosphates (OTP(n)) have been successfully utilized for the preparation of a 106-member library of triazole containing benzothiaoxazepine-1,1-dioxides. This report demonstrates the...
8.
Organ M, Hanson P, Rolfe A, Samarakoon T, Ullah F
J Flow Chem
. 2011 Nov;
1(1):32-39.
PMID: 22116791
The generation of stereochemically-rich benzothiaoxazepine-1,1'-dioxides for enrichment of high-throughput screening collections is reported. Utilizing a microwave-assisted, continuous flow organic synthesis platform (MACOS), scale-out of core benzothiaoxazepine-1,1'-dioxide scaffolds has been achieved...
9.
Maity P, Kainz Q, Faisal S, Rolfe A, Samarakoon T, Basha F, et al.
Chem Commun (Camb)
. 2011 Oct;
47(46):12524-6.
PMID: 22027744
The utilization of a monomer-on-monomer (MoM) intramolecular Mitsunobu cyclization reaction employing norbornenyl-tagged (Nb-tagged) reagents is reported for the synthesis of benzofused thiadiazepine-dioxides. Facile purification was achieved via ring-opening metathesis (ROM)...
10.
Rolfe A, Young K, Hanson P
European J Org Chem
. 2011 Sep;
(31):5254-5262.
PMID: 19603087
The development of a new method for the synthesis of 1,1-dioxido-1,2-benzisothiazoline-3-acetic acid by a domino process is reported whereby a classical Heck reaction is coupled to an intramolecular aza-Michael reaction....