Alan Morgan
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Explore the profile of Alan Morgan including associated specialties, affiliations and a list of published articles.
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62
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1418
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Recent Articles
1.
Gadhia A, Barker E, Morgan A, Barclay J
Epilepsia Open
. 2024 May;
9(4):1458-1466.
PMID: 38813985
Objective: GABA receptor subunit mutations pose a significant risk for genetic generalized epilepsy; however, there are over 150 identified variants, many with unknown or unvalidated pathogenicity. We aimed to develop...
2.
Barker E, Morgan A, Barclay J
Cell Tissue Res
. 2024 Feb;
396(1):41-55.
PMID: 38403745
Cysteine string protein (CSP) is a member of the DnaJ/Hsp40 family of molecular chaperones. CSP is enriched in neurons, where it mainly localises to synaptic vesicles. Mutations in CSP-encoding genes...
3.
Barker E, Milburn A, Helassa N, Hammond D, Sanchez-Soriano N, Morgan A, et al.
Biochem J
. 2024 Jan;
PMID: 38193346
Cysteine string protein α (CSPα), also known as DNAJC5, is a member of the DnaJ/Hsp40 family of co-chaperones. The name derives from a cysteine-rich domain, palmitoylation of which enables localization...
4.
Barker E, Morgan A, Barclay J
Hum Mol Genet
. 2022 Oct;
32(11):1772-1785.
PMID: 36282524
Autosomal dominant adult-onset neuronal ceroid lipofuscinosis (ANCL) is a rare neurodegenerative disorder characterized by progressive dementia and premature death. Four ANCL-causing mutations have been identified, all mapping to the DNAJC5...
5.
Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer's disease
Rupawala H, Shah K, Davies C, Rose J, Colom-Cadena M, Peng X, et al.
Brain Commun
. 2022 Aug;
4(4):fcac192.
PMID: 35928052
In Alzheimer's disease, synapse loss causes memory and cognitive impairment. However, the mechanisms underlying synaptic degeneration in Alzheimer's disease are not well understood. In the hippocampus, alterations in the level...
6.
Campion R, Bloxam L, Burrow K, Brownridge P, Pentland D, Thomas P, et al.
Biochem J
. 2021 Oct;
478(24):4153-4167.
PMID: 34661239
Dietary restriction (DR) has been shown to increase lifespan in organisms ranging from yeast to mammals. This suggests that the underlying mechanisms may be evolutionarily conserved. Indeed, upstream signalling pathways,...
7.
Jones A, Barker-Haliski M, Ilie A, Herd M, Baxendale S, Holdsworth C, et al.
Epilepsia
. 2020 Aug;
61(10):2106-2118.
PMID: 32797628
Objective: Current medicines are ineffective in approximately one-third of people with epilepsy. Therefore, new antiseizure drugs are urgently needed to address this problem of pharmacoresistance. However, traditional rodent seizure and...
8.
Zhu B, Mak J, Morris A, Marson A, Barclay J, Sills G, et al.
Epilepsia
. 2020 Mar;
61(4):810-821.
PMID: 32112430
Objective: Genetic variants in STXBP1, which encodes the conserved exocytosis protein Munc18-1, are associated with a variety of infantile epilepsy syndromes. We aimed to develop an in vivo Caenorhabditis elegans...
9.
Huber R, Hughes S, Liu W, Morgan A, Tuxworth R, Russell C
Biochim Biophys Acta Mol Basis Dis
. 2019 Nov;
1866(9):165614.
PMID: 31783156
The NCLs (neuronal ceroid lipofuscinosis) are forms of neurodegenerative disease that affect people of all ages and ethnicities but are most prevalent in children. Commonly known as Batten disease, this...
10.