Alan H Lazarus
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Explore the profile of Alan H Lazarus including associated specialties, affiliations and a list of published articles.
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75
Citations
1178
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Recent Articles
1.
Won K, Gil Gonzalez L, Cruz-Leal Y, Pavon Oro A, Lazarus A
J Immunol
. 2024 Mar;
212(10):1531-1539.
PMID: 38506555
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts primarily due to antiplatelet autoantibodies. Anti-D is a donor-derived polyclonal Ab against the rhesus D Ag on erythrocytes...
2.
Gil Gonzalez L, Won K, Tawhidi Z, Cummins E, Cruz-Leal Y, Tundidor Cabado Y, et al.
Blood Adv
. 2024 Feb;
8(8):1869-1879.
PMID: 38330193
Fc gamma receptor (FcγR) IIIA is an important receptor for immunoglobulin G (IgG) and is involved in immune defense mechanisms as well as tissue destruction in some autoimmune diseases including...
3.
Cruz-Leal Y, Norris P, Gil Gonzalez L, Marjoram D, Wabnitz H, Shan Y, et al.
Blood
. 2023 Nov;
143(9):807-821.
PMID: 37946269
Red blood cell (RBC) alloimmunization to paternal antigens during pregnancy can cause hemolytic disease of the fetus and newborn (HDFN). This severe and potentially fatal neonatal disorder can be prevented...
4.
5.
Norris P, Tawhidi Z, Sachs U, Cserti-Gazdewich C, Lin Y, Callum J, et al.
Blood Adv
. 2023 Apr;
7(14):3561-3572.
PMID: 37042934
Humoral antiplatelet factors, such as autoantibodies, are thought to primarily clear platelets by triggering macrophage phagocytosis in immune thrombocytopenia (ITP). However, there are few studies characterizing the capacity and mechanisms...
6.
Roeser A, Lazarus A, Mahevas M
Br J Haematol
. 2023 Apr;
203(1):43-53.
PMID: 37002711
Immune thrombocytopenia (ITP) is an acquired bleeding disorder mediated by pathogenic autoantibodies secreted by plasma cells (PCs) in many patients. In refractory ITP patients, the persistence of splenic and bone...
7.
Wabnitz H, Cruz-Leal Y, Lazarus A
Transfusion
. 2023 Feb;
63(4):696-702.
PMID: 36802050
Background: The administration of anti-D for the prevention of hemolytic disease of the fetus and newborn is one of the most successful clinical uses of the phenomenon of antibody-mediated immune...
8.
Wabnitz H, Cruz-Leal Y, Lazarus A
Transfusion
. 2023 Jan;
63(3):619-628.
PMID: 36591986
Background: Despite the vast antigen disparity between donor and recipient red blood cells (RBCs), only 2%-6% of transfusion patients mount an alloantibody response. Recently, RBC antigen density has been proposed...
9.
Gil Gonzalez L, Fernandez-Marrero Y, Norris P, Tawhidi Z, Shan Y, Cruz-Leal Y, et al.
PLoS One
. 2022 Dec;
17(12):e0278365.
PMID: 36516219
Fc gamma receptors (FcγRs) are critical effector receptors for immunoglobulin G (IgG) antibodies. On macrophages, FcγRs mediate multiple effector functions, including phagocytosis, but the individual contribution of specific FcγRs to...
10.
Norris P, Kaur G, Khan R, Zhu G, Ni H, Lazarus A
Blood
. 2021 Mar;
137(15):2114-2124.
PMID: 33662988
Monoclonal immunoglobulin G (IgG) antibodies to CD44 (anti-CD44) are anti-inflammatory in numerous murine autoimmune models, but the mechanisms are poorly understood. Anti-CD44 anti-inflammatory activity shows complete therapeutic concordance with IV...