Alan F Zahorchak
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Explore the profile of Alan F Zahorchak including associated specialties, affiliations and a list of published articles.
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29
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1509
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Recent Articles
1.
Liu S, Zahorchak A, Dobrowolski S, Metes D, Thomson A, Abdelsamed H
Sci Rep
. 2024 Nov;
14(1):28748.
PMID: 39567586
During differentiation of precursor cells into their destination cell type, cell fate decisions are enforced by a broad array of epigenetic modifications, including DNA methylation, which is reflected by the...
2.
Tran L, Macedo C, Zahorchak A, Gu X, Elinoff B, Singhi A, et al.
Sci Transl Med
. 2023 Oct;
15(717):eadf4287.
PMID: 37820009
Immune cell-based therapies are promising strategies to facilitate immunosuppression withdrawal after organ transplantation. Regulatory dendritic cells (DCreg) are innate immune cells that down-regulate alloimmune responses in preclinical models. Here, we...
3.
Zahorchak A, DeRiggi M, Muzzio J, Sutherland V, Humar A, Lakkis F, et al.
Cytotherapy
. 2023 Jan;
25(4):432-441.
PMID: 36639251
Background Aims: Regulatory (or "tolerogenic") dendritic cells (DCregs) are a highly promising, innovative cell therapy for the induction or restoration of antigen-specific tolerance in immune-mediated inflammatory disorders. These conditions include...
4.
Sasaki K, Moussawy M, Abou-Daya K, Macedo C, Hosni-Ahmed A, Liu S, et al.
Commun Biol
. 2022 Jun;
5(1):634.
PMID: 35768564
T cells are endowed with the capacity to sense their environment including other T cells around them. They do so to set their numbers and activation thresholds. This form of...
5.
Ezzelarab M, Zhang H, Sasaki K, Lu L, Zahorchak A, van der Windt D, et al.
Transplantation
. 2021 Feb;
105(9):1965-1979.
PMID: 33587433
Background: Regulatory T cell (Treg) therapy is a promising approach to amelioration of allograft rejection and promotion of organ transplant tolerance. However, the fate of infused Treg, and how this...
6.
Macedo C, Tran L, Zahorchak A, Dai H, Gu X, Ravichandran R, et al.
Am J Transplant
. 2020 Nov;
21(7):2372-2386.
PMID: 33171019
Regulatory dendritic cells (DCreg) promote transplant tolerance following their adoptive transfer in experimental animals. We investigated the feasibility, safety, fate, and impact on host T cells of donor monocyte-derived DCreg...
7.
Ezzelarab M, Perez-Gutierrez A, Humar A, Wijkstrom M, Zahorchak A, Lu-Casto L, et al.
Transpl Immunol
. 2019 Jul;
56:101225.
PMID: 31330261
Myeloid-derived suppressor cells (MDSC) are a heterogenous population of immunosuppressive myeloid cells now considered important immune regulatory cells in diverse clinical conditions, including cancer, chronic inflammatory disorders and transplantation. In...
8.
Zahorchak A, Perez-Gutierrez A, Ezzelarab M, Thomson A
Cell Immunol
. 2018 May;
329:50-55.
PMID: 29803290
Putative monocytic myeloid-derived suppressor cells (mMDSC; lineageHLA-DR) were generated in 7-day cultures from normal rhesus macaque bone marrow (BM) cells in GM-CSF and IL-6. Three subsets were identified based on...
9.
Zahorchak A, Macedo C, Hamm D, Butterfield L, Metes D, Thomson A
Cell Immunol
. 2017 Dec;
323:9-18.
PMID: 29217299
Human regulatory dendritic cells (DCreg) were generated from CD14 immunobead-purified or elutriated monocytes in the presence of vitamin D3 and IL-10. They exhibited similar, low levels of costimulatory CD80 and...
10.
Thomson A, Zahorchak A, Ezzelarab M, Butterfield L, Lakkis F, Metes D
Front Immunol
. 2016 Feb;
7:15.
PMID: 26858719
Dendritic cells (DC) are rare, professional antigen-presenting cells with ability to induce or regulate alloimmune responses. Regulatory DC (DCreg) with potential to down-modulate acute and chronic inflammatory conditions that occur...