Alan C Spivey
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Explore the profile of Alan C Spivey including associated specialties, affiliations and a list of published articles.
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70
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Recent Articles
11.
Alamillo-Ferrer C, Nielsen C, Salzano A, Companyo X, Di Sanza R, Spivey A, et al.
J Org Chem
. 2021 Feb;
86(5):4326-4335.
PMID: 33567827
Downstream intermediates are crucial for the reactivity and selectivity of aminocatalytic reactions. We present an analysis of the stereopreference in aminocatalytic downstream intermediates, which reveals an inconspicuous mechanism of chiral...
12.
Cesarec S, Robson J, Carroll L, Aboagye E, Spivey A
Curr Radiopharm
. 2020 Sep;
14(2):101-106.
PMID: 32895047
Background: One of the challenges in positron emission tomography (PET) is labelling complex aliphatic molecules. Objective: This study aimed to develop a method of metal-catalysed radiofluorination that is site-selective and...
13.
Nielsen C, White A, Sale D, Bures J, Spivey A
J Org Chem
. 2019 Oct;
84(22):14965-14973.
PMID: 31630524
Upon treatment with a combination of HFIP and an organic sulfonic acid, alkenes behave as Brønsted bases and protonate to give carbocations which can be trapped by electron-rich arenes. The...
14.
Ferris T, Carroll L, Mease R, Spivey A, Aboagye E
Tetrahedron Lett
. 2019 Jun;
60(13):936-939.
PMID: 31217642
Herein, we report an efficient new method for the iodination of terminal alkynes using stoichiometric KI and CuSO in a mix of acetonitrile and acetate buffer that holds promise for...
15.
Cryer A, Chan C, Eftychidou A, Maksoudian C, Mahesh M, Tetley T, et al.
ACS Appl Mater Interfaces
. 2019 Apr;
11(18):16336-16346.
PMID: 30986026
Gold nanoparticles (AuNPs) have emerged as promising drug delivery candidates that can be leveraged for cancer therapy. Lung cancer (LC) is a heterogeneous disease that imposes a significant burden on...
16.
Boddy A, Cordier C, Goldberg K, Madin A, Spivey A, Bull J
Org Lett
. 2019 Mar;
21(6):1818-1822.
PMID: 30829041
The ring expansion of 2-ester-2-arylazetidine carbamates can be achieved using Brønsted acids to form 6,6-disubstituted 1,3-oxazinan-2-ones. The reaction is rapid at room temperature with Boc or Cbz derivatives and proceeds...
17.
Nielsen C, Mooij W, Sale D, Rzepa H, Bures J, Spivey A
Chem Sci
. 2019 Feb;
10(2):406-412.
PMID: 30713643
Herein we report a combined experimental and computational investigation of the acid catalyzed cyclocondensation reaction between styrenyl homoallylic alcohols and salicylaldehyde to form furanochromanes. We disclose a previously unreported isomerisation...
18.
Boddy A, Affron D, Cordier C, Rivers E, Spivey A, Bull J
Angew Chem Int Ed Engl
. 2018 Dec;
58(5):1458-1462.
PMID: 30516342
Methods that provide rapid access to new heterocyclic structures in biologically relevant chemical space provide important opportunities in drug discovery. Here, a strategy is described for the preparation of 2,2-disubstituted...
19.
Spivey A, Andrews B
Angew Chem Int Ed Engl
. 2018 May;
40(17):3131-3134.
PMID: 29712049
The single symmetry-breaking transformation of a relatively simple meso compound can provide highly expedient access to a wide variety of usefully functionalized chiral building blocks. Recent advances in asymmetric desymmetrization,...
20.
Griffiths K, Tsipis A, Kumar P, Townrow O, Abdul-Sada A, Akien G, et al.
Inorg Chem
. 2017 Aug;
56(16):9563-9573.
PMID: 28783350
Michael addition (MA) is one of the most well studied chemical transformation in synthetic chemistry. Here, we report the synthesis and crystal structures of a library of 3d/4f coordination clusters...