Alain Grodet
Overview
Explore the profile of Alain Grodet including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
14
Citations
619
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0
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Recent Articles
1.
Girard M, Lacaille F, Verkarre V, Mategot R, Feldmann G, Grodet A, et al.
Hepatology
. 2013 Dec;
60(1):301-10.
PMID: 24375397
Unlabelled: Microvillous inclusion disease (MVID) is a congenital disorder of the enterocyte related to mutations in the MYO5B gene, leading to intractable diarrhea often necessitating intestinal transplantation (ITx). Among our...
2.
Thachil E, Hugot J, Arbeille B, Paris R, Grodet A, Peuchmaur M, et al.
Gastroenterology
. 2012 Jan;
142(5):1097-1099.e4.
PMID: 22285936
Autophagy-related 16 like-1 (ATG16L-1), immunity-related GTPase-M (IRGM), and nucleotide-binding oligomerization domain-containing 2 (NOD2) regulate autophagy, and variants in these genes have been associated with predisposition to Crohn's disease (CD). However,...
3.
Treton X, Pedruzzi E, Cazals-Hatem D, Grodet A, Panis Y, Groyer A, et al.
Gastroenterology
. 2011 Jun;
141(3):1024-35.
PMID: 21699776
Background & Aims: Ulcerative colitis (UC) is a chronic inflammatory disorder that affects the colonic epithelium. Epidemiology studies indicate an environmental component is involved in pathogenesis, although the primary changes...
4.
Rautou P, Cazals-Hatem D, Feldmann G, Mansouri A, Grodet A, Barge S, et al.
Am J Pathol
. 2011 Jun;
178(6):2708-15.
PMID: 21641393
Autophagy is a regulated process that can be involved in the elimination of intracellular microorganisms and in antigen presentation. Some in vitro studies have shown an altered autophagic response in...
5.
Coant N, Ben Mkaddem S, Pedruzzi E, Guichard C, Treton X, Ducroc R, et al.
Mol Cell Biol
. 2010 Mar;
30(11):2636-50.
PMID: 20351171
The homeostatic self-renewal of the colonic epithelium requires coordinated regulation of the canonical Wnt/beta-catenin and Notch signaling pathways to control proliferation and lineage commitment of multipotent stem cells. However, the...
6.
Tabet L, Bussy C, Amara N, Setyan A, Grodet A, Rossi M, et al.
J Toxicol Environ Health A
. 2008 Nov;
72(2):60-73.
PMID: 19034795
The aim of this study was to evaluate adverse effects of multiwalled carbon nanotubes (MWCNT), produced for industrial purposes, on the human epithelial cell line A549. MWCNT were dispersed in...
7.
Igoudjil A, Abbey-Toby A, Begriche K, Grodet A, Chataigner K, Peytavin G, et al.
Antivir Ther
. 2007 Jun;
12(3):389-400.
PMID: 17591029
Objective: Stavudine (d4T), a nucleoside reverse-transcriptase inhibitor (NRTI), can induce lipoatrophy, fatty liver, hyperlactataemia and abnormal liver tests. NRTI toxicity is usually ascribed to mitochondrial DNA (mtDNA) depletion and impaired...
8.
Cazanave S, Berson A, Haouzi D, Vadrot N, Fau D, Grodet A, et al.
J Hepatol
. 2007 Feb;
46(5):858-68.
PMID: 17275124
Background/aims: The agonistic Jo2 anti-Fas antibody reproduces human fulminant hepatitis in mice. We tested the hypothesis that enhancing hepatic glutathione (GSH) stores may prevent Jo2-induced apoptosis. Methods: We fed mice...
9.
Berson A, Cazanave S, Descatoire V, Tinel M, Grodet A, Wolf C, et al.
J Pharmacol Exp Ther
. 2006 Apr;
318(1):444-54.
PMID: 16617166
Like other nonsteroidal anti-inflammatory drugs, nimesulide (4-nitro-2-phenoxymethane-sulfoanilide) triggers hepatitis in a few recipients. Although nimesulide has been shown to uncouple mitochondrial respiration and cause hepatocyte necrosis in the absence of...
10.
Guichard C, Pedruzzi E, Fay M, Marie J, Braut-Boucher F, Daniel F, et al.
Carcinogenesis
. 2006 Mar;
27(9):1812-27.
PMID: 16524888
The search for effective chemopreventive compounds is a major challenge facing research into preventing the progression of cancer cells. The naturally occurring polyphenol antioxidants look very promising, but their mechanism...