Akito Kadotani
Overview
Explore the profile of Akito Kadotani including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
124
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Recent Articles
1.
Kamagata K, Kanbayashi S, Koda S, Kadotani A, Ubukata O, Tashima T
Biochem Biophys Res Commun
. 2023 Apr;
662:119-125.
PMID: 37104882
TAR DNA-binding protein 43 (TDP-43), aggregation prone protein, is a potential target of drug discovery for amyotrophic lateral sclerosis. The molecular binders, targeting the disordered low complexity domain (LCD) relevant...
2.
Sogabe S, Sakamoto K, Kamada Y, Kadotani A, Fukuda Y, Sakamoto J
Biochem Biophys Res Commun
. 2017 Mar;
486(3):620-625.
PMID: 28315327
Keap1 constitutively binds to the transcription factor Nrf2 to promote its degradation, resulting in negative modulation of genes involved in cellular protection against oxidative stress. Keap1 is increasingly recognized as...
3.
Sakamoto K, Adachi Y, Komoike Y, Kamada Y, Koyama R, Fukuda Y, et al.
Biochem Biophys Res Commun
. 2017 Jan;
483(1):183-190.
PMID: 28039053
Dedicator of cytokinesis 2 (DOCK2) is a key molecule for lymphocyte activation and migration. DOCK2 interacts with Ras-related C3 botulinus toxin substrate 1 (Rac1, GTPase) and mediates the GDP-GTP exchange...
4.
Sakamoto K, Sogabe S, Kamada Y, Matsumoto S, Kadotani A, Sakamoto J, et al.
Biochem Biophys Res Commun
. 2016 Nov;
482(2):195-201.
PMID: 27836545
The phospholipid hydroperoxidase glutathione peroxidase (GPX4) is an enzyme that reduces lipid hydroperoxides in lipid membranes. Recently, GPX4 has been investigated as a target molecule that induces iron-dependent cell death...
5.
Lanier M, Ambrus G, Cole D, Davenport R, Ellery J, Fosbeary R, et al.
J Med Chem
. 2014 May;
57(12):5459-63.
PMID: 24847974
Catechol O-methyl transferase belongs to the diverse family of S-adenosyl-l-methionine transferases. It is a target involved in the treatment of Parkinson's disease. Here we present a fragment-based screening approach to...
6.
Eiki J, Nagata Y, Futamura M, Sasaki-Yamamoto K, Iino T, Nishimura T, et al.
Mol Pharmacol
. 2011 Sep;
80(6):1156-65.
PMID: 21937665
Glucokinase activators (GKAs) are small-molecule agents that enhance glucose sensing by pancreatic β cells and glucose metabolism by hepatocytes. There is strong interest in these agents as potential therapies for...
7.
Kadotani A, Tsuchiya Y, Hatakeyama H, Katagiri H, Kanzaki M
Am J Physiol Endocrinol Metab
. 2009 Sep;
297(6):E1291-303.
PMID: 19755671
In skeletal muscle, saturated free fatty acids (FFAs) act as proinflammatory stimuli, and cyclooxygenase-2 (COX-2) is a pro/anti-inflammatory enzyme induced at sites of inflammation, which contributes to prostaglandin production. However,...
8.
Nedachi T, Kadotani A, Ariga M, Katagiri H, Kanzaki M
Am J Physiol Endocrinol Metab
. 2008 Jan;
294(4):E668-78.
PMID: 18230695
Nutrition availability is one of the major environmental signals influencing cell fate, such as proliferation, differentiation, and apoptosis, often functioning in concert with other humoral factors, including insulin. Herein, we...
9.
Kadotani A, Fujimura M, Nakamura T, Ohyama S, Harada N, Maruki H, et al.
Arch Biochem Biophys
. 2007 Sep;
466(2):283-9.
PMID: 17880910
To investigate the effect of elevation of liver glycogen synthase (GYS2) activity on glucose and glycogen metabolism, we performed adenoviral overexpression of the mutant GYS2 with six serine-to-alanine substitutions in...
10.
Futamura M, Hosaka H, Kadotani A, Shimazaki H, Sasaki K, Ohyama S, et al.
J Biol Chem
. 2006 Oct;
281(49):37668-74.
PMID: 17028192
Glucokinase (GK) plays a key role in the control of blood glucose homeostasis. We identified a small molecule GK activator, compound A, that increased the glucose affinity and maximal velocity...