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Akito Eguchi

Explore the profile of Akito Eguchi including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 314
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Recent Articles
1.
Coleman R, Eguchi A, Lieu M, Roy R, Barr E, Ibetti J, et al.
Sci Signal . 2021 Mar; 14(676). PMID: 33785612
Aberrant changes in gene expression underlie the pathogenesis and progression of pressure-overload heart failure, leading to maladaptive cardiac hypertrophy, ventricular remodeling, and contractile dysfunction. Signaling through the G protein G...
2.
Eguchi A, Coleman R, Gresham K, Gao E, Ibetti J, Chuprun J, et al.
Proc Natl Acad Sci U S A . 2021 Jan; 118(5). PMID: 33500351
Pathological remodeling of the heart is a hallmark of chronic heart failure (HF) and these structural changes further perpetuate the disease. Cardiac fibroblasts are the critical cell type that is...
3.
Beyett T, Fraley A, Labudde E, Patra D, Coleman R, Eguchi A, et al.
Proc Natl Acad Sci U S A . 2019 Jul; 116(32):15895-15900. PMID: 31337679
G protein-coupled receptor (GPCR) kinases (GRKs) are responsible for initiating desensitization of activated GPCRs. GRK5 is potently inhibited by the calcium-sensing protein calmodulin (CaM), which leads to nuclear translocation of...
4.
de Lucia C, Eguchi A, Koch W
Front Pharmacol . 2018 Aug; 9:904. PMID: 30147654
Heart failure (HF) has become increasingly common within the elderly population, decreasing their survival and overall quality of life. In fact, despite the improvements in treatment, many elderly people suffer...
5.
Cannavo A, Liccardo D, Eguchi A, Elliott K, Traynham C, Ibetti J, et al.
Nat Commun . 2016 Mar; 7:10877. PMID: 26932512
Hyper-aldosteronism is associated with myocardial dysfunction including induction of cardiac fibrosis and maladaptive hypertrophy. Mechanisms of these cardiotoxicities are not fully understood. Here we show that mineralocorticoid receptor (MR) activation...
6.
Shanmughapriya S, Rajan S, Hoffman N, Higgins A, Tomar D, Nemani N, et al.
Mol Cell . 2015 Sep; 60(1):47-62. PMID: 26387735
Mitochondrial permeability transition is a phenomenon in which the mitochondrial permeability transition pore (PTP) abruptly opens, resulting in mitochondrial membrane potential (ΔΨm) dissipation, loss of ATP production, and cell death....
7.
Eguchi A, Eguchi S, Tilley D
Hypertension . 2013 Apr; 61(5):e46. PMID: 23547237
No abstract available.
8.
Takayanagi T, Eguchi A, Takaguri A, Hinoki A, Bourne A, Elliott K, et al.
Atherosclerosis . 2013 Mar; 228(1):90-3. PMID: 23535568
Objective: The Max-interacting protein Mnt is a transcriptional repressor that can antagonize the transcriptional and proliferation-related activities of Myc. Here, we tested the hypothesis that Mnt is a negative regulator...