Robert M Williams
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Explore the profile of Robert M Williams including associated specialties, affiliations and a list of published articles.
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155
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2643
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Recent Articles
1.
El-Desoky A, Inada N, Maeyama Y, Kato H, Hitora Y, Sebe M, et al.
J Nat Prod
. 2021 Aug;
84(9):2475-2485.
PMID: 34464116
Fifteen new isopimarane-type diterpenes, taichunins E-S (-), and a new 20--isopimarane, taichunin T (), together with four known compounds were isolated from (IBT 19404). The structures of these new compounds...
2.
Ye Y, Du L, Zhang X, Newmister S, McCauley M, Alegre-Requena J, et al.
Nat Catal
. 2020 Sep;
3(6):497-506.
PMID: 32923978
Fungal bicyclo[2.2.2]diazaoctane indole alkaloids represent an important family of natural products with a wide-spectrum of biological activities. Although biomimetic total syntheses of representative compounds have been reported, the details of...
3.
Sadahiro Y, Kato H, Williams R, Tsukamoto S
J Nat Prod
. 2020 Apr;
83(5):1368-1373.
PMID: 32301614
A new isoindolinone alkaloid, irpexine (), was isolated as a racemate, along with a known green pigment, hypoxyxylerone (), from the coculture of two endophytic fungi, and . Compound was...
4.
Fraley A, Tran H, Kelly S, Newmister S, Tripathi A, Kato H, et al.
Chembiochem
. 2020 Apr;
21(17):2449-2454.
PMID: 32246875
The fungal indole alkaloids are a unique class of complex molecules that have a characteristic bicyclo[2.2.2]diazaoctane ring and frequently contain a spiro-oxindole moiety. While various strains produce these compounds, an...
5.
Li S, Newmister S, Lowell A, Zi J, Chappell C, Yu F, et al.
Angew Chem Int Ed Engl
. 2020 Feb;
59(21):8166-8172.
PMID: 32052896
Stereospecific polycyclic core formation of hapalindoles and fischerindoles is controlled by Stig cyclases through a three-step cascade involving Cope rearrangement, 6-exo-trig cyclization, and a final electrophilic aromatic substitution. Reported here...
6.
Thielman J, Sherman D, Williams R
J Org Chem
. 2020 Jan;
85(5):3812-3823.
PMID: 31970985
New structural classes of antibiotics are rare, structurally novel broad-spectrum antibiotics exceptionally so. The recently discovered baulamycins constitute a remarkable example of these highly prized compounds and, as such, have...
7.
Fraley A, Caddell Haatveit K, Ye Y, Kelly S, Newmister S, Yu F, et al.
J Am Chem Soc
. 2020 Jan;
142(5):2244-2252.
PMID: 31904957
The paraherquamides are potent anthelmintic natural products with complex heptacyclic scaffolds. One key feature of these molecules is the spiro-oxindole moiety that lends a strained three-dimensional architecture to these structures....
8.
Dan Q, Newmister S, Klas K, Fraley A, McAfoos T, Somoza A, et al.
Nat Chem
. 2019 Sep;
11(11):972-980.
PMID: 31548667
Prenylated indole alkaloids such as the calmodulin-inhibitory malbrancheamides and anthelmintic paraherquamides possess great structural diversity and pharmaceutical utility. Here, we report complete elucidation of the malbrancheamide biosynthetic pathway accomplished through...
9.
Beyett T, Fraley A, Labudde E, Patra D, Coleman R, Eguchi A, et al.
Proc Natl Acad Sci U S A
. 2019 Jul;
116(32):15895-15900.
PMID: 31337679
G protein-coupled receptor (GPCR) kinases (GRKs) are responsible for initiating desensitization of activated GPCRs. GRK5 is potently inhibited by the calcium-sensing protein calmodulin (CaM), which leads to nuclear translocation of...
10.
Chaabane M, Williams R, Stephens A, Park J
Bioinformatics
. 2019 Jul;
36(1):73-80.
PMID: 31268128
Motivation: Over the past two decades, a circular form of RNA (circular RNA), produced through alternative splicing, has become the focus of scientific studies due to its major role as...