Alpha 2.0
Login Register
» Authors » Akira Tohgo

Akira Tohgo

Explore the profile of Akira Tohgo including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 506
Followers 0
Related Specialties
Biochemistry
Neurology
Molecular Biology
Top 10 Co-Authors
Hiroshi Takeshima
Taisuke Miyazaki
Masahiko Watanabe
Miyuki Nishi
Hiroyuki Sakagami
Louis M Luttrell
Eric W Choy
Kristen L Pierce
Mineko Kengaku
Robert J Lefkowitz
Published In
J Biol Chem
Gene
J Neurochem
Mol Cell Neurosci
Nat Neurosci
Affiliations
Soon will be listed here.
Recent Articles
1.
Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family
Miyazaki T, Hashimoto K, Uda A, Sakagami H, Nakamura Y, Saito S, et al.
FEBS Lett . 2006 Jul; 580(17):4057-64. PMID: 16814779
By DNA cloning, we have identified the BSRP (brain-specific receptor-like proteins) family of three members in mammalian genomes. BSRPs were predominantly expressed in the soma and dendrites of neurons and...
2.
Impaired cerebellar functions in mutant mice lacking DNER
Tohgo A, Eiraku M, Miyazaki T, Miura E, Kawaguchi S, Nishi M, et al.
Mol Cell Neurosci . 2005 Nov; 31(2):326-33. PMID: 16298139
DNER is a transmembrane protein carrying extracellular EGF repeats and is strongly expressed in Purkinje cells (PCs) in the cerebellum. Current study indicated that DNER functions as a new Notch...
3.
Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6
Nakazawa T, Takasawa S, Noguchi N, Nata K, Tohgo A, Mori M, et al.
Gene . 2005 Aug; 360(1):55-64. PMID: 16122887
Cyclic ADP-ribose (cADPR) induces the release of Ca2+ from microsomes of pancreatic islets for insulin secretion. It has been demonstrated that cADPR binds to FK506-binding protein 12.6 (FKBP 12.6) on...
4.
DNER acts as a neuron-specific Notch ligand during Bergmann glial development
Eiraku M, Tohgo A, Ono K, Kaneko M, Fujishima K, Hirano T, et al.
Nat Neurosci . 2005 Jun; 8(7):873-80. PMID: 15965470
Differentiation of CNS glia is regulated by Notch signaling through neuron-glia interaction. Here, we identified Delta/Notch-like EGF-related receptor (DNER), a neuron-specific transmembrane protein, as a previously unknown ligand of Notch...
5.
Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells
Matsuya S, Sakagami H, Tohgo A, Owada Y, Shin H, Takeshima H, et al.
J Neurochem . 2005 Apr; 93(3):674-85. PMID: 15836626
EFA6C is a third member of the EFA6 family of guanine nucleotide exchange factors (GEFs) for ADP-ribosylation factor 6 (ARF6). In this study, we first demonstrated that EFA6C indeed activated...
6.
The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation
Tohgo A, Choy E, Gesty-Palmer D, Pierce K, Laporte S, Oakley R, et al.
J Biol Chem . 2002 Dec; 278(8):6258-67. PMID: 12473660
By binding to agonist-activated G protein-coupled receptors (GPCRs), beta-arrestins mediate homologous receptor desensitization and endocytosis via clathrin-coated pits. Recent data suggest that beta-arrestins also contribute to GPCR signaling by acting...
7.
beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation
Tohgo A, Pierce K, Choy E, Lefkowitz R, Luttrell L
J Biol Chem . 2002 Jan; 277(11):9429-36. PMID: 11777902
beta-Arrestins are cytosolic proteins that mediate homologous desensitization of G protein-coupled receptors (GPCRs) by binding to agonist-occupied receptors and by uncoupling them from heterotrimeric G proteins. The recent finding that...