Ake Nilsson
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Explore the profile of Ake Nilsson including associated specialties, affiliations and a list of published articles.
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52
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915
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Recent Articles
1.
Alyamani M, Kadivar M, Erjefalt J, Johansson-Lindbom B, Duan R, Nilsson A, et al.
Front Immunol
. 2023 Feb;
13:1050625.
PMID: 36741374
Background And Aim: Alkaline sphingomyelinase (NPP7) is expressed by intestinal epithelial cells and is crucial for the digestion of dietary sphingomyelin. NPP7 also inactivates proinflammatory mediators including platelet-activating factor and...
2.
Nilsson A, Duan R, Ohlsson L
Front Nutr
. 2021 Sep;
8:724006.
PMID: 34490332
Milk polar lipids provide choline, ethanolamine, and polyunsaturated fatty acids, which are needed for the growth and plasticity of the tissues in a suckling child. They may also inhibit cholesterol...
3.
Nilsson A, Duan R
Am J Physiol Gastrointest Liver Physiol
. 2018 Dec;
316(4):G425-G445.
PMID: 30576217
The digestion of choline phospholipids is important for choline homeostasis, lipid signaling, postprandial lipid and energy metabolism, and interaction with intestinal bacteria. The digestion is mediated by the combined action...
4.
Zhang P, Chen Y, Zhang T, Zhu J, Zhao L, Li J, et al.
J Lipid Res
. 2018 Aug;
59(10):1841-1850.
PMID: 30087205
Intestinal alkaline SMase (Alk-SMase) cleaves phosphocholine from SM, platelet-activating factor (PAF), and lysophosphatidylcholine. We recently found that colitis-associated colon cancer was 4- to 5-fold enhanced in Alk-SMase KO mice. Here,...
5.
Almhojd U, Lingstrom P, Nilsson A, Noren J, Siljestrom S, Ostlund A, et al.
Caries Res
. 2017 May;
51(3):255-263.
PMID: 28501859
Dyes currently used to stain carious dentine have a limited capacity to discriminate normal dentine from carious dentine, which may result in overexcavation. Consequently, finding a selective dye is still...
6.
Nilsson A
J Pediatr
. 2016 May;
173 Suppl:S53-9.
PMID: 27234412
Sphingomyelin (SM), glycosphingolipids, and gangliosides are important polar lipids in the milk fat globule membrane but are not found in standard milk replacement formulas. Because digestion and absorption of SM...
7.
Chen Y, Zhang P, Xu S, Yang L, Voss U, Ekblad E, et al.
Mol Cancer Ther
. 2014 Nov;
14(1):259-67.
PMID: 25381265
Intestinal alkaline sphingomyelinase (alk-SMase) generates ceramide and inactivates platelet-activating factor (PAF) and was previously suggested to have anticancer properties. The direct evidence is still lacking. We studied colonic tumorigenesis in...
8.
Almhojd U, Noren J, Arvidsson A, Nilsson A, Lingstrom P
Oral Health Dent Manag
. 2014 Oct;
13(3):735-44.
PMID: 25284549
Apart from the Maillard reaction, other processes, such as esterification, take place in carious tissue. The aim of the present study was to analyse sound and carious dentine in terms...
9.
Duan R, Hindorf U, Cheng Y, Bergenzaun P, Hall M, Hertervig E, et al.
BMC Gastroenterol
. 2014 Aug;
14:138.
PMID: 25100243
Background: Alkaline sphingomyelinase (NPP7) is an ecto-enzyme expressed in intestinal mucosa, which hydrolyses sphingomyelin (SM) to ceramide and inactivates platelet activating factor. It is also expressed in human liver and...
10.
Zhang P, Chen Y, Cheng Y, Hertervig E, Ohlsson L, Nilsson A, et al.
Am J Physiol Gastrointest Liver Physiol
. 2014 Mar;
306(10):G903-8.
PMID: 24650549
We previously showed that dietary sphingomyelin (SM) inhibited cholesterol absorption in animals. The key enzyme hydrolyzing SM in the gut is alkaline sphingomyelinase (alk-SMase, nucleotide pyrophosphatase/phosphodiesterase 7). Here using the...