Ajith V Pankajam
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Explore the profile of Ajith V Pankajam including associated specialties, affiliations and a list of published articles.
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11
Citations
82
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Recent Articles
1.
Pavani R, Tripathi V, Vrtis K, Zong D, Chari R, Callen E, et al.
Science
. 2024 Jun;
385(6710):eado3867.
PMID: 38900911
Using CRISPR-Cas9 nicking enzymes, we examined the interaction between the replication machinery and single-strand breaks, one of the most common forms of endogenous DNA damage. We show that replication fork...
2.
Liu A, Peng B, Pankajam A, Duong T, Pryhuber G, Scheuermann R, et al.
bioRxiv
. 2024 May;
PMID: 38712147
The use of single cell/nucleus RNA sequencing (scRNA-seq) technologies that quantitively describe cell transcriptional phenotypes is revolutionizing our understanding of cell biology, leading to new insights in cell type identification,...
3.
Dash S, Joshi S, Pankajam A, Shinohara A, Nishant K
Genetics
. 2023 Dec;
226(3).
PMID: 38124392
Meiotic crossovers are initiated from programmed DNA double-strand breaks. The Msh4-Msh5 heterodimer is an evolutionarily conserved mismatch repair-related protein complex that promotes meiotic crossovers by stabilizing strand invasion intermediates and...
4.
Zong D, Koussa N, Cornwell J, Pankajam A, Kruhlak M, Wong N, et al.
Genes Dev
. 2023 Nov;
37(19-20):913-928.
PMID: 37932011
Addiction to the WRN helicase is a unique vulnerability of human cancers with high levels of microsatellite instability (MSI-H). However, while prolonged loss of WRN ultimately leads to cell death,...
5.
Zong D, Koussa N, Cornwell J, Pankajam A, Kruhlak M, Wong N, et al.
bioRxiv
. 2023 Sep;
PMID: 37662356
Addiction to the WRN helicase is a unique vulnerability of human cancers with high levels of microsatellite instability (MSI-H). However, while prolonged loss of WRN ultimately leads to cell death,...
6.
Nandanan K, Salim S, Pankajam A, Shinohara M, Lin G, Chakraborty P, et al.
Genetics
. 2021 Dec;
219(2).
PMID: 34849874
In the baker's yeast Saccharomyces cerevisiae, most of the meiotic crossovers are generated through a pathway involving the highly conserved mismatch repair related Msh4-Msh5 complex. To understand the role of...
7.
Pankajam A, Dash S, Saifudeen A, Dutta A, Nishant K
G3 (Bethesda)
. 2020 Jul;
10(9):3309-3319.
PMID: 32727920
A growing body of evidence suggests that mutation rates exhibit intra-species specific variation. We estimated genome-wide loss of heterozygosity (LOH), gross chromosomal changes, and single nucleotide mutation rates to determine...
8.
Giri D, Pankajam A, Nishant K, Kasbekar D
G3 (Bethesda)
. 2019 Mar;
9(5):1487-1496.
PMID: 30842206
Meiotic silencing by unpaired DNA (MSUD), an RNAi-mediated gene silencing process, is efficient in crosses made in the standard Oak Ridge (OR) genetic background. However, MSUD was decidedly less efficient...
9.
Chakraborty P, Pankajam A, Dutta A, Nishant K
IUBMB Life
. 2018 Jun;
70(8):743-752.
PMID: 29934971
Diploid organisms undergo meiosis to produce haploid germ cells. Crossover events during meiosis promote genetic diversity and facilitate accurate chromosome segregation. The baker's yeast Saccharomyces cerevisiae is extensively used as...
10.
Dutta A, Lin G, Pankajam A, Chakraborty P, Bhat N, Steinmetz L, et al.
G3 (Bethesda)
. 2017 Sep;
7(11):3669-3679.
PMID: 28916648
Mutation and recombination are the major sources of genetic diversity in all organisms. In the baker's yeast, all mutation rate estimates are in homozygous background. We determined the extent of...