Ajit Wilson
Overview
Explore the profile of Ajit Wilson including associated specialties, affiliations and a list of published articles.
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20
Citations
359
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Recent Articles
1.
Kochumon S, Al-Sayyar A, Jacob T, Bahman F, Akhter N, Wilson A, et al.
Front Immunol
. 2024 Oct;
15:1430187.
PMID: 39351229
Increased MMP-9 expression in the tumor microenvironment (TME) plays a crucial role in the extracellular matrix remodeling to facilitate cancer invasion and metastasis. However, the mechanism of MMP-9 upregulation in...
2.
Jacob T, Sindhu S, Hasan A, Malik M, Arefanian H, Al-Rashed F, et al.
Front Microbiol
. 2024 Aug;
15:1407258.
PMID: 39165573
High-fat diets (HFDs) shape the gut microbiome and promote obesity, inflammation, and liver steatosis. Fish and soybean are part of a healthy diet; however, the impact of these fats, in...
3.
Kochumon S, Malik M, Sindhu S, Arefanian H, Jacob T, Bahman F, et al.
Nutrients
. 2024 Jun;
16(12).
PMID: 38931284
Background: High-fat diets cause gut dysbiosis and promote triglyceride accumulation, obesity, gut permeability changes, inflammation, and insulin resistance. Both cocoa butter and fish oil are considered to be a part...
4.
Bahman F, Al-Roub A, Akhter N, Madhoun A, Wilson A, Almansour N, et al.
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928498
Extensive evidence supports the connection between obesity-induced inflammation and the heightened expression of IL-6 adipose tissues. However, the mechanism underlying the IL-6 exacerbation in the adipose tissue remains unclear. There...
5.
Akhter N, Wilson A, Arefanian H, Thomas R, Kochumon S, Al-Rashed F, et al.
Int J Mol Sci
. 2023 Oct;
24(20).
PMID: 37894865
Obesity and metabolic syndrome involve chronic low-grade inflammation called metabolic inflammation as well as metabolic derangements from increased endotoxin and free fatty acids. It is debated whether the endoplasmic reticulum...
6.
Al-Roub A, Akhter N, Al-Rashed F, Wilson A, Alzaid F, Al-Mulla F, et al.
Sci Rep
. 2023 Sep;
13(1):14351.
PMID: 37658104
Studies have established the association between increased plasma levels of matrix metalloproteinase (MMP)-9 and adipose tissue inflammation. Tumor necrosis factor α (TNFα) was elevated in obesity and is involved in...
7.
Akhter N, Kochumon S, Hasan A, Wilson A, Nizam R, Madhoun A, et al.
J Inflamm Res
. 2022 Aug;
15:4291-4302.
PMID: 35923906
Background: Overexpression of CCL2 (MCP-1) has been implicated in pathogenesis of metabolic conditions, such as obesity and T2D. However, the mechanisms leading to increased CCL2 expression in obesity are not...
8.
Akhter N, Wilson A, Thomas R, Al-Rashed F, Kochumon S, Al-Roub A, et al.
Int J Mol Sci
. 2021 Oct;
22(19).
PMID: 34638857
IL-8/MCP-1 act as neutrophil/monocyte chemoattractants, respectively. Oxidative stress emerges as a key player in the pathophysiology of obesity. However, it remains unclear whether the TNF-α/oxidative stress interplay can trigger IL-8/MCP-1...
9.
Al-Roub A, Akhter N, Al-Sayyar A, Wilson A, Thomas R, Kochumon S, et al.
Int J Mol Sci
. 2021 Jul;
22(14).
PMID: 34299302
Short-chain fatty acid (SCFA) acetate, a byproduct of dietary fiber metabolism by gut bacteria, has multiple immunomodulatory functions. The anti-inflammatory role of acetate is well documented; however, its effect on...
10.
Sindhu S, Akhter N, Wilson A, Thomas R, Arefanian H, Madhoun A, et al.
Cells
. 2020 Aug;
9(8).
PMID: 32751118
Metabolic inflammation is associated with increased expression of saturated free fatty acids, proinflammatory cytokines, chemokines, and adipose oxidative stress. Macrophage inflammatory protein (MIP)-1α recruits the inflammatory cells such as monocytes,...