Ajasja Ljubetic
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Explore the profile of Ajasja Ljubetic including associated specialties, affiliations and a list of published articles.
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24
Citations
236
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Recent Articles
1.
Snoj J, Zhou W, Ljubetic A, Jerala R
Curr Opin Biotechnol
. 2025 Jan;
92:103256.
PMID: 39827499
Recent advances in protein engineering have revolutionized the design of bionanomolecular assemblies for functional therapeutic and biotechnological applications. This review highlights the progress in creating complex protein architectures, encompassing both...
2.
Vidmar S, Smidlehner T, Aupic J, Strmsek Z, Ljubetic A, Xiao F, et al.
Angew Chem Int Ed Engl
. 2024 Dec;
:e202422075.
PMID: 39666653
Versatile DNA and polypeptide-based structures have been designed based on complementary modules. However, polypeptides can also form higher oligomeric states. We investigated the introduction of tetrameric modules as a substitute...
3.
Coupling of Spectrin Repeat Modules for the Assembly of Nanorods and Presentation of Protein Domains
Mezgec K, Snoj J, Ulcakar L, Ljubetic A, Znidaric M, Skarabot M, et al.
ACS Nano
. 2024 Oct;
18(42):28748-28763.
PMID: 39392430
Modular protein engineering is a powerful approach for fabricating high-molecular-weight assemblies and biomaterials with nanoscale precision. Herein, we address the challenge of designing an extended nanoscale filamentous architecture inspired by...
4.
Baryshev A, La Fleur A, Groves B, Michel C, Baker D, Ljubetic A, et al.
Nat Chem Biol
. 2024 Aug;
20(11):1514-1523.
PMID: 39192093
Protein-protein interactions (PPIs) regulate many cellular processes and engineered PPIs have cell and gene therapy applications. Here, we introduce massively parallel PPI measurement by sequencing (MP3-seq), an easy-to-use and highly...
5.
Xiao F, Luo L, Liu X, Ljubetic A, Jin N, Jerala R, et al.
J Phys Chem B
. 2024 Jun;
128(26):6272-6282.
PMID: 38904939
Coiled-coil protein origami (CCPO) is a modular strategy for the de novo design of polypeptide nanostructures. It represents a type of modular design based on pairwise-interacting coiled-coil (CC) units with...
6.
Plaper T, Merljak E, Fink T, Satler T, Ljubetic A, Lainscek D, et al.
Cell Discov
. 2024 Jan;
10(1):8.
PMID: 38228615
The regulation of protein function by external or internal signals is one of the key features of living organisms. The ability to directly control the function of a selected protein...
7.
Boldridge W, Ljubetic A, Kim H, Lubock N, Szilagyi D, Lee J, et al.
Nat Commun
. 2023 Aug;
14(1):4636.
PMID: 37532706
Protein-protein interactions (PPIs) are crucial for biological functions and have applications ranging from drug design to synthetic cell circuits. Coiled-coils have been used as a model to study the sequence...
8.
Baryshev A, La Fleur A, Groves B, Michel C, Baker D, Ljubetic A, et al.
bioRxiv
. 2023 Feb;
PMID: 36798377
Protein-protein interactions (PPIs) regulate many cellular processes, and engineered PPIs have cell and gene therapy applications. Here we introduce massively parallel protein-protein interaction measurement by sequencing (MP3-seq), an easy-to-use and...
9.
Hunt A, Case J, Park Y, Cao L, Wu K, Walls A, et al.
Sci Transl Med
. 2022 Apr;
14(646):eabn1252.
PMID: 35412328
New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here, we used a cell-free expression workflow to rapidly...
10.
Leman J, Lyskov S, Lewis S, Adolf-Bryfogle J, Alford R, Barlow K, et al.
Nat Commun
. 2021 Nov;
12(1):6947.
PMID: 34845212
Each year vast international resources are wasted on irreproducible research. The scientific community has been slow to adopt standard software engineering practices, despite the increases in high-dimensional data, complexities of...