Ahmed M Metwaly
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Explore the profile of Ahmed M Metwaly including associated specialties, affiliations and a list of published articles.
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92
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1108
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Recent Articles
1.
Elkaeed E, Elkady H, Khattab A, Yousef R, Al-Ghulikah H, Husein D, et al.
PLoS One
. 2025 Jan;
20(1):e0316146.
PMID: 39869618
This study presents T-1-NBAB, a new compound derived from the natural xanthine alkaloid theobromine, aimed at inhibiting VEGFR-2, a crucial protein in angiogenesis. T-1-NBAB's potential to interacts with and inhibit...
2.
Metwaly A, El-Fakharany E, Alsfouk A, Ibrahim I, Elkaeed E, Eissa I
Curr Med Chem
. 2025 Jan;
PMID: 39757685
Introduction: In our quest to identify potent inhibitors against SARS-CoV-2, an extensive investigation was conducted for the binding and inhibitory efficacy of Rutin against nine SARS-CoV-2 proteins. Method: The first...
3.
Metwaly A, Elkaeed E, Alsfouk A, Ibrahim I, Elkady H, Eissa I
Antivir Ther
. 2024 Dec;
29(6):13596535241305536.
PMID: 39639531
Background: The COVID-19 pandemic has created an urgent need for effective therapeutic agents. The SARS-CoV-2 Main Protease (M) plays a crucial role in viral replication and immune evasion, making it...
4.
Metwaly A, El-Fakharany E, Alsfouk A, Ibrahim I, Elkaeed E, Eissa I
PLoS One
. 2024 Dec;
19(12):e0312866.
PMID: 39625895
To find an effective inhibitor for SARS-CoV-2, Quercetin's chemical structure was compared to nine ligands associated with nine key SARS-CoV-2 proteins. It was found that Quercetin closely resembles Remdesivir, the...
5.
Eissa I, Elgammal W, Mahdy H, Zara S, Carradori S, Husein D, et al.
RSC Adv
. 2024 Nov;
14(48):35505-35519.
PMID: 39507692
Objective: This study aims to investigate the potential of designed 2,3-dihydro-1,3,4-thiadiazole derivatives as anti-proliferative agents targeting VEGFR-2, utilizing a multidimensional approach combining and analyses. Methods: The synthesized derivatives were evaluated...
6.
Elkady H, Elgammal W, Mahdy H, Zara S, Carradori S, Husein D, et al.
Comput Biol Chem
. 2024 Sep;
113:108221.
PMID: 39332241
In this study, we present the design, synthesis, and evaluation of six new thiadiazole derivatives designed as VEGFR-2 inhibitors. The most promising compound, 18b, demonstrated promising inhibitory activity against VEGFR-2,...
7.
Sobh E, Dahab M, Elkaeed E, Alsfouk B, Ibrahim I, Metwaly A, et al.
Med Chem
. 2024 May;
20(9):876-899.
PMID: 38798211
Background: Vascular endothelial growth factor receptor-2 (VEGFR-2) is a critical protein involved in tumor progression, making it an attractive target for cancer therapy. Objective: This study aimed to synthesize and...
8.
Eissa I, Yousef R, Elkaeed E, Alsfouk A, Husein D, Ibrahim I, et al.
ACS Omega
. 2024 Apr;
9(14):15861-15881.
PMID: 38617602
Aim: The aim of this study was to design and examine a novel epidermal growth factor receptor (EGFR) inhibitor with apoptotic properties by utilizing the essential structural characteristics of existing...
9.
Abdel-Kader M, Radwan M, Metwaly A, Eissa I, Hazekamp A, ElSohly M
Molecules
. 2024 Mar;
29(6).
PMID: 38542886
is one of the oldest plants utilized by humans for both economic and medical purposes. Although the use of cannabis started millennia ago in the Eastern hemisphere, its use has...
10.
Elkady H, Mahdy H, Taghour M, Dahab M, Elwan A, Hagras M, et al.
Biochim Biophys Acta Gen Subj
. 2024 Mar;
1868(6):130599.
PMID: 38521471
Background: VEGFR-2 has emerged as a prominent positive regulator of cancer progression. Aim: Discovery of new anticancer agents and apoptotic inducers targeting VEGFR-2. Methods: Design and synthesis of new thiazolidine-2,4-diones...