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Ibrahim M Ibrahim

Explore the profile of Ibrahim M Ibrahim including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 141
Citations 1535
Followers 0
Related Specialties
Biochemistry
Chemistry
Biology
Top 10 Co-Authors
Ibrahim H Eissa
Eslam B Elkaeed
Ahmed M Metwaly
Hazem Elkady
Dalal Z Husein
Abdo A Elfiky
Aisha A Alsfouk
Reda G Yousef
Bshra A Alsfouk
Mohammed A Dahab
Published In
J Biomol Struct Dyn
RSC Adv
Molecules
J Infect
Sci Rep
Affiliations
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Recent Articles
1.
Design and synthesis of novel cyclohexanecarboxamides with anticonvulsant effect by activating Nrf2-ARE pathway
Abd-Allah W, Abdel-Maksoud M, Elbaset M, Korany R, Ibrahim I, Hassan R
Bioorg Chem . 2025 Mar; 159:108357. PMID: 40088686
This study investigated a series of novel cyclohexanecarboxamide derivatives 4a-e, 5a-e and 6a-e as anticonvulsant and neuroprotective agents. Compounds 4a-e, 5a-e, and 6a-e were synthesized starting from cyclohexanone and aniline...
2.
Integrated in silico and in vitro exploration of the anti-VEGFR-2 activities of a semisynthetic xanthine alkaloid inhibiting breast cancer
Elkaeed E, Elkady H, Khattab A, Yousef R, Al-Ghulikah H, Husein D, et al.
PLoS One . 2025 Jan; 20(1):e0316146. PMID: 39869618
This study presents T-1-NBAB, a new compound derived from the natural xanthine alkaloid theobromine, aimed at inhibiting VEGFR-2, a crucial protein in angiogenesis. T-1-NBAB's potential to interacts with and inhibit...
3.
Identification of promising dipeptidyl peptidase-4 and protein tyrosine phosphatase 1B inhibitors from selected terpenoids through molecular modeling
Ogunyemi O, Gyebi G, Olawale F, Ibrahim I, Iwaloye O, Fabusiwa M, et al.
Bioinform Adv . 2025 Jan; 5(1):vbae205. PMID: 39846080
Motivation: Investigating novel drug-target interactions is crucial for expanding the chemical space of emerging therapeutic targets in human diseases. Herein, we explored the interactions of dipeptidyl peptidase-4 and protein tyrosine...
4.
Integrated in Silico and in Vitro Studies of Rutin's Potential against SARS-CoV-2 through the Inhibition of the RNA-dependent RNA Polymerase
Metwaly A, El-Fakharany E, Alsfouk A, Ibrahim I, Elkaeed E, Eissa I
Curr Med Chem . 2025 Jan; PMID: 39757685
Introduction: In our quest to identify potent inhibitors against SARS-CoV-2, an extensive investigation was conducted for the binding and inhibitory efficacy of Rutin against nine SARS-CoV-2 proteins. Method: The first...
5.
Repurposing FDA-approved drugs for COVID-19: targeting the main protease through multi-phase approach
Metwaly A, Elkaeed E, Alsfouk A, Ibrahim I, Elkady H, Eissa I
Antivir Ther . 2024 Dec; 29(6):13596535241305536. PMID: 39639531
Background: The COVID-19 pandemic has created an urgent need for effective therapeutic agents. The SARS-CoV-2 Main Protease (M) plays a crucial role in viral replication and immune evasion, making it...
6.
Integrated study of Quercetin as a potent SARS-CoV-2 RdRp inhibitor: Binding interactions, MD simulations, and In vitro assays
Metwaly A, El-Fakharany E, Alsfouk A, Ibrahim I, Elkaeed E, Eissa I
PLoS One . 2024 Dec; 19(12):e0312866. PMID: 39625895
To find an effective inhibitor for SARS-CoV-2, Quercetin's chemical structure was compared to nine ligands associated with nine key SARS-CoV-2 proteins. It was found that Quercetin closely resembles Remdesivir, the...
7.
Pharmacophore-based virtual screening, molecular docking, and molecular dynamics investigation for the identification of novel, marine aromatase inhibitors
Kotb M, Abdelmawgood I, Ibrahim I
BMC Chem . 2024 Nov; 18(1):235. PMID: 39593184
Breast cancer remains a leading cause of mortality among women worldwide. Our current research focuses on identifying effective therapeutic agents by targeting the human aromatase enzyme. Aromatase inhibitors (AIs) have...
8.
Design and synthesis of new nicotinamides as immunomodulatory VEGFR-2 inhibitors and apoptosis inducers
Yousef R, Eissa I, Elkady H, Mehany A, Abo-Saif M, Radwan M, et al.
Future Med Chem . 2024 Nov; 16(24):2583-2598. PMID: 39540547
Nicotinamide-based VEGFR-2 inhibitors have good contribution in drug discovery. Development of novel nicotinamides as VEGFR-2 inhibitors. different and assays were conducted to evaluate the VEGFR-2 inhibition and cytotoxicity. Compound displayed...
9.
Design, synthesis, and evaluation of novel thiadiazole derivatives as potent VEGFR-2 inhibitors: a comprehensive and study
Eissa I, Elgammal W, Mahdy H, Zara S, Carradori S, Husein D, et al.
RSC Adv . 2024 Nov; 14(48):35505-35519. PMID: 39507692
Objective: This study aims to investigate the potential of designed 2,3-dihydro-1,3,4-thiadiazole derivatives as anti-proliferative agents targeting VEGFR-2, utilizing a multidimensional approach combining and analyses. Methods: The synthesized derivatives were evaluated...
10.
Anti-proliferative 2,3-dihydro-1,3,4-thiadiazoles targeting VEGFR-2: Design, synthesis, in vitro, and in silico studies
Elkady H, Elgammal W, Mahdy H, Zara S, Carradori S, Husein D, et al.
Comput Biol Chem . 2024 Sep; 113:108221. PMID: 39332241
In this study, we present the design, synthesis, and evaluation of six new thiadiazole derivatives designed as VEGFR-2 inhibitors. The most promising compound, 18b, demonstrated promising inhibitory activity against VEGFR-2,...