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» Authors » Ahmed M El-Dessouki

Ahmed M El-Dessouki

Explore the profile of Ahmed M El-Dessouki including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 12
Citations 59
Followers 0
Related Specialties
Chemistry
Biochemistry
Pharmacology
Top 10 Co-Authors
Ahmed A Al-Karmalawy
Haytham O Tawfik
Marwa Sharaky
Nahed A Raslan
Moataz A Shaldam
Riham A El-Shiekh
Samar Ibrahim
Amany A Alzokaky
Mai H A Mousa
Hala F Zaki
Published In
Naunyn Schmiedebergs Arch Pharmacol
J Med Chem
Life Sci
Bioorg Chem
Mol Neurobiol
Affiliations
Soon will be listed here.
Recent Articles
1.
Orientin: a comprehensive review of a promising bioactive flavonoid
Fahmy M, Sadek M, Abdou K, El-Dessouki A, El-Shiekh R, Khalaf S
Inflammopharmacology . 2025 Mar; PMID: 40056319
Medicinal herbs continue to play an important part in modern drugs and healthcare because customers think that most of them have fewer or milder side effects than traditional modern medicines....
2.
Modulation of AMPK by esomeprazole and canagliflozin mitigates methotrexate-induced hepatotoxicity: involvement of MAPK/JNK/ERK, JAK1/STAT3, and PI3K/Akt signaling pathways
El-Dessouki A, Kaml M, El-Yamany M
Naunyn Schmiedebergs Arch Pharmacol . 2025 Mar; PMID: 40055205
This research investigated the hepatoprotective effects of esomeprazole (ESOM) and canagliflozin (CANA) against methotrexate-induced liver toxicity, focusing on AMPK modulation and its regulation of MAPK/JNK/ERK, JAK1/STAT3, and PI3K/Akt pathways. Fifty...
3.
Bridging Gaps in Migraine Management: A Comprehensive Review of Conventional Treatments, Natural Supplements, Complementary Therapies, and Lifestyle Modifications
Abo-Elghiet F, Elosaily H, Hussein D, El-Shiekh R, Aaqoulah A, Yousef E, et al.
Pharmaceuticals (Basel) . 2025 Feb; 18(2). PMID: 40005953
: Migraine, a complex neurological condition, poses significant challenges for both sufferers and healthcare providers. While prescription medications play a vital role in managing migraine attacks, the quest for natural,...
4.
Natural remedies proposed for the management of diabetic retinopathy (DR): diabetic complications
Khidr E, Morad N, Hatem S, El-Dessouki A, Mohamed A, El-Shiekh R, et al.
Naunyn Schmiedebergs Arch Pharmacol . 2025 Feb; PMID: 39954069
Diabetic retinopathy (DR) represents a significant and serious complication associated with diabetes mellitus (DM), often resulting in considerable visual impairment or even blindness. The intricate pathological processes underlying DR complicate...
5.
Febuxostat protects from Doxorubicin induced hepatotoxicity in rats via regulation of NF-κB p65/NLRP3 inflammasome and SIRT-1/AMPK pathways
El-Dessouki A, Yousef E, Raslan N, Alwakeel A, Ibrahim S, Alzokaky A
Naunyn Schmiedebergs Arch Pharmacol . 2025 Feb; PMID: 39951115
Doxorubicin (DOX) is a highly potent broad-spectrum anticancer drug, but it has severe side effects, including hepatotoxicity. Therefore, we evaluated the efficacy of febuxostat (FBX), a specific inhibitor of xanthine...
6.
Dabigatran attenuates methotrexate-induced hepatotoxicity by regulating coagulation, endothelial dysfunction, and the NF-kB/IL-1β/MCP-1 and TLR4/NLRP3 signaling pathways
El-Dessouki A, Alzokaky A, Raslan N, Ibrahim S, Selim H, Al-Karmalawy A
Naunyn Schmiedebergs Arch Pharmacol . 2024 Nov; PMID: 39527308
This study examines Dabigatran's (Dab) capacity to mitigate methotrexate (MTX)-induced coagulation disorders and endothelial dysfunction, while exploring its effects on oxidative stress and inflammatory pathways (NF-kB/IL-1β/MCP-1, TLR4/NLRP3) in reducing hepatotoxicity....
7.
Muti-target rationale design of novel substituted N-phenyl-2-((6-phenylpyridazin-3-yl)thio)acetamide candidates as telomerase/JAK1/STAT3/TLR4 inhibitors: In vitro and in vivo investigations
Shaldam M, Mousa M, Tawfik H, El-Dessouki A, Sharaky M, Saleh M, et al.
Bioorg Chem . 2024 Sep; 153:107843. PMID: 39332072
In this work, additional effort was applied to design new BIBR1532-based analogues with potential inhibitory activity against telomerase and acting as multitarget antitumor candidates to overcome the resistance problem. Therefore,...
8.
Exploring chromone-2-carboxamide derivatives for triple-negative breast cancer targeting EGFR, FGFR3, and VEGF pathways: Design, synthesis, and preclinical insights
El-Gamil D, Zaky M, Maximous P, Sharaky M, El-Dessouki A, Riad N, et al.
Drug Dev Res . 2024 Jul; 85(5):e22228. PMID: 38952003
Chromone-based compounds have established cytotoxic, antiproliferative, antimetastatic, and antiangiogenic effects on various cancer cell types via modulating different molecular targets. Herein, 17 novel chromone-2-carboxamide derivatives were synthesized and evaluated for...
9.
Piracetam mitigates nephrotoxicity induced by cisplatin via the AMPK-mediated PI3K/Akt and MAPK/JNK/ERK signaling pathways
El-Dessouki A, Alzokaky A, Raslan N, Ibrahim S, Salama L, Yousef E
Int Immunopharmacol . 2024 Jun; 137:112511. PMID: 38909496
Aims: Cisplatin (CDDP) is commonly employed as an antineoplastic agent, but its use is significantly limited by the occurrence of dose-dependent nephrotoxicity, the detailed mechanisms of which remain unclear. This...
10.
A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments
Hefny S, El-Moselhy T, El-Din N, Ammara A, Angeli A, Ferraroni M, et al.
Eur J Med Chem . 2024 May; 274:116527. PMID: 38810335
Herein, we describe the design and synthesis of novel aryl pyrimidine benzenesulfonamides APBSs 5a-n, 6a-c, 7a-b, and 8 as pazopanib analogues to explore new potent and selective inhibitors for the...