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» Authors » Ahmed M El-Dessouki

Ahmed M El-Dessouki

Explore the profile of Ahmed M El-Dessouki including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 12
Citations 59
Followers 0
Related Specialties
Chemistry
Biochemistry
Pharmacology
Top 10 Co-Authors
Ahmed A Al-Karmalawy
Haytham O Tawfik
Marwa Sharaky
Nahed A Raslan
Moataz A Shaldam
Riham A El-Shiekh
Samar Ibrahim
Amany A Alzokaky
Mai H A Mousa
Hala F Zaki
Published In
Naunyn Schmiedebergs Arch Pharmacol
J Med Chem
Life Sci
Bioorg Chem
Mol Neurobiol
Affiliations
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Recent Articles
11.
Rationale design of novel substituted 1,3,5-triazine candidates as dual IDH1(R132H)/ IDH2(R140Q) inhibitors with high selectivity against acute myeloid leukemia: In vitro and in vivo preclinical investigations
Tawfik H, Mousa M, Zaky M, El-Dessouki A, Sharaky M, Abdullah O, et al.
Bioorg Chem . 2024 May; 149:107483. PMID: 38805913
In this study, novel substituted 1,3,5-triazine candidates (4a-d, 5a-j, and 6a-d) were designed as second-generation small molecules to act as dual IDH1 and IDH2 inhibitors according to the pharmacophoric features...
12.
Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-κB/NLRP3 inflammasome axis and attenuating oxidative stress in mice
Antar S, Abdo W, Helal A, Abduh M, Hakami Z, Germoush M, et al.
Life Sci . 2024 May; 348:122688. PMID: 38710284
Coenzyme Q10 (CoQ10) occurs naturally in the body and possesses antioxidant and cardioprotective effects. Cardiotoxicity has emerged as a serious effect of the exposure to cadmium (Cd). This study investigated...
13.
Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, , , and Investigations of Coumarin-Based Thiazoles
Hefny S, El-Moselhy T, El-Din N, Giovannuzzi S, Bin Traiki T, Vaali-Mohammed M, et al.
J Med Chem . 2024 Apr; 67(9):7406-7430. PMID: 38642371
A dual-targeting approach is predicted to yield better cancer therapy outcomes. Consequently, a series of coumarin-based thiazoles (-, , and -) were designed and constructed as potential carbonic anhydrase (CA)...
14.
Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments
Al-Karmalawy A, Mousa M, Sharaky M, Mourad M, El-Dessouki A, Hamouda A, et al.
J Med Chem . 2023 Dec; 67(1):492-512. PMID: 38117230
Herein, modifications to the previously reported BIBR1591 were conducted to obtain bioisosteric candidates with improved activities. The % inhibition of the newly afforded candidates against the telomerase target was investigated....
15.
C-phycocyanin protects against ethanol-induced gastric ulcers in rats: Role of HMGB1/NLRP3/NF-κB pathway
Alzokaky A, Abdelkader E, El-Dessouki A, Khaleel S, Raslan N
Basic Clin Pharmacol Toxicol . 2020 Apr; 127(4):265-277. PMID: 32306544
Gastric ulcer is a widespread inflammatory disease with high socio-economic burden. C-phycocyanin is one of the active constituents of Spirulina microalgae, and although it is well known for its antioxidant...
16.
Zafirlukast and vincamine ameliorate tamoxifen-induced oxidative stress and inflammation: Role of the JNK/ERK pathway
El-Dessouki A, El Fattah M, Awad A, Zaki H
Life Sci . 2018 Apr; 202:78-88. PMID: 29626531
Aims: This study investigated the hepatoprotective effects of both zafirlukast and vincamine and their possible role in the treatment of tamoxifen-induced liver injury in rats. Materials And Methods: Female Wistar...
17.
Neuroprotective Effects of Simvastatin and Cilostazol in L-Methionine-Induced Vascular Dementia in Rats
El-Dessouki A, Galal M, Awad A, Zaki H
Mol Neurobiol . 2016 Aug; 54(7):5074-5084. PMID: 27544235
Vascular dementia (VaD) is a degenerative cerebrovascular disorder that leads to progressive decline in cognitive abilities and memory. Several reports demonstrated that oxidative stress and endothelial dysfunction are principal pathogenic...