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Ahmad Reza Mehdipour

Explore the profile of Ahmad Reza Mehdipour including associated specialties, affiliations and a list of published articles. Areas
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Articles 28
Citations 1020
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Recent Articles
1.
Jungnickel K, Guelle O, Iguchi M, Dong W, Kotov V, Gabriel F, et al.
Nat Cell Biol . 2024 Jun; 26(7):1047-1061. PMID: 38839979
The lysosomal degradation of macromolecules produces diverse small metabolites exported by specific transporters for reuse in biosynthetic pathways. Here we deorphanized the major facilitator superfamily domain containing 1 (MFSD1) protein,...
2.
van Schie L, Van Breedam W, Roels C, Schepens B, Frank M, Mehdipour A, et al.
MAbs . 2023 May; 15(1):2210709. PMID: 37211816
As small and stable high-affinity antigen binders, VHHs boast attractive characteristics both for therapeutic use in various disease indications, and as versatile reagents in research and diagnostics. To further increase...
3.
Lettl C, Schindele F, Mehdipour A, Steiner T, Ring D, Brack-Werner R, et al.
Cell Chem Biol . 2023 Apr; 30(5):499-512.e5. PMID: 37100053
Respiratory complex I is a multicomponent enzyme conserved between eukaryotic cells and many bacteria, which couples oxidation of electron donors and quinone reduction with proton pumping. Here, we report that...
4.
Zhu R, Canena D, Sikora M, Klausberger M, Seferovic H, Mehdipour A, et al.
Nat Commun . 2023 Feb; 14(1):1142. PMID: 36854739
No abstract available.
5.
Zhu R, Canena D, Sikora M, Klausberger M, Seferovic H, Mehdipour A, et al.
Nat Commun . 2022 Dec; 13(1):7926. PMID: 36566234
Recent waves of COVID-19 correlate with the emergence of the Delta and the Omicron variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby forming...
6.
Lambert E, Mehdipour A, Schmidt A, Hummer G, Perez C
Nat Commun . 2022 Feb; 13(1):1022. PMID: 35197476
Transport of lipids across membranes is fundamental for diverse biological pathways in cells. Multiple ion-coupled transporters take part in lipid translocation, but their mechanisms remain largely unknown. Major facilitator superfamily...
7.
Zhao J, Xie H, Mehdipour A, Safarian S, Ermler U, Munke C, et al.
Proc Natl Acad Sci U S A . 2021 Nov; 118(46). PMID: 34753818
Multidrug and toxic compound extrusion (MATE) transporters are widespread in all domains of life. Bacterial MATE transporters confer multidrug resistance by utilizing an electrochemical gradient of H or Na to...
8.
Mukherjee R, Bhattacharya A, Bojkova D, Mehdipour A, Shin D, Khan K, et al.
J Biol Chem . 2021 Jul; 297(2):100925. PMID: 34214498
Apart from prevention using vaccinations, the management options for COVID-19 remain limited. In retrospective cohort studies, use of famotidine, a specific oral H2 receptor antagonist (antihistamine), has been associated with...
9.
Mehdipour A, Hummer G
Proc Natl Acad Sci U S A . 2021 Apr; 118(19). PMID: 33903171
Binding of the spike protein of SARS-CoV-2 to the human angiotensin-converting enzyme 2 (ACE2) receptor triggers translocation of the virus into cells. Both the ACE2 receptor and the spike protein...
10.
Shin D, Bhattacharya A, Cheng Y, Campos Alonso M, Mehdipour A, van der Heden van Noort G, et al.
Elife . 2020 Nov; 9. PMID: 33185526
causes a severe pneumonia known as Legionnaires' disease. During the infection, Legionella injects more than 300 effector proteins into host cells. Among them are enzymes involved in altering the host-ubiquitination...