Agnieszka U Blachnio-Zabielska
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Explore the profile of Agnieszka U Blachnio-Zabielska including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Blachnio-Zabielska A, Hady H, Markowski A, Kurianiuk A, Karwowska A, Gorski J, et al.
Int J Mol Sci
. 2018 Dec;
19(12).
PMID: 30545025
Ceramide accumulation in muscle and in liver is implicated in the induction of insulin resistance. Much less in known about the role of ceramide in adipose tissue. The aim of...
12.
Zabielski P, Daniluk J, Hady H, Markowski A, Imierska M, Gorski J, et al.
J Cell Physiol
. 2018 Aug;
234(2):1851-1861.
PMID: 30067865
Liver, as one of the most important organs involved in lipids and glucose metabolism, is perceived as a key tissue for pharmacotherapy of insulin resistance (IRes) and type 2 diabetes....
13.
Zabielski P, Hady H, Chacinska M, Roszczyc K, Gorski J, Blachnio-Zabielska A
Sci Rep
. 2018 May;
8(1):7249.
PMID: 29739997
We sought to determine whether metformin treatment reverses a high-fat diet (HFD)-induced hepatic insulin resistance (IRes) and to identify lipid intermediates involved in induction of liver IRes. The experiments were...
14.
Zabielski P, Chacinska M, Charkiewicz K, Baranowski M, Gorski J, Blachnio-Zabielska A
J Endocrinol
. 2017 May;
233(3):329-340.
PMID: 28522731
Intramuscular accumulation of bioactive lipids leads to insulin resistance and type 2 diabetes (T2D). There is lack of consensus concerning which of the lipid mediators has the greatest impact on...
15.
Chung J, Koutsari C, Blachnio-Zabielska A, Hames K, Jensen M
Diabetes
. 2017 May;
66(8):2082-2091.
PMID: 28483801
We investigated the relationship between insulin resistance markers and subsarcolemmal (SS) and intramyofibrillar (IMF) ceramide concentrations, as well as the contribution of plasma palmitate (6.5-h infusion of [U-C]palmitate) to intramyocellular...
16.
Blachnio-Zabielska A, Chacinska M, Vendelbo M, Zabielski P
Cell Physiol Biochem
. 2016 Dec;
40(5):1207-1220.
PMID: 27960149
Background/aims: Muscle bioactive lipids accumulation leads to several disorder states. The most common are insulin resistance (IR) and type 2 diabetes. There is an ongoing debate which of the lipid...
17.
Sogaard D, Ostergard T, Blachnio-Zabielska A, Baranowski M, Vigelso A, Andersen J, et al.
J Diabetes Res
. 2016 Oct;
2016:2372741.
PMID: 27777958
Ceramide and diacylglycerol (DAG) may be involved in the early phase of insulin resistance but data are inconsistent in man. We evaluated if an increase in insulin sensitivity after endurance...
18.
Baranowski M, Blachnio-Zabielska A, Charmas M, Helge J, Dela F, Ksiazek M, et al.
Eur J Appl Physiol
. 2014 Dec;
115(5):993-1003.
PMID: 25519954
Purpose: Sphingosine-1-phosphate (S1P) regulates cardiovascular function and plays an important role in muscle biology. We have previously reported that cycling exercise increased plasma S1P. Here, we investigated the effect of...
19.
Baranowski M, Zabielski P, Blachnio-Zabielska A, Harasim E, Chabowski A, Gorski J
Cell Physiol Biochem
. 2014 Apr;
33(4):1047-57.
PMID: 24732673
Background/aim: Liver X receptors (LXRs) are ligand-activated transcription factors that were shown to stimulate hepatic lipogenesis leading to liver steatosis and hypertriglyceridemia. Despite their pro-lipogenic action, LXR activators normalize glycemia...
20.
Blachnio-Zabielska A, Zabielski P, Jensen M
J Lipid Res
. 2013 Mar;
54(6):1705-1711.
PMID: 23511896
Diacylglycerols (DAG) are important lipid metabolites thought to induce muscle insulin resistance when present in excess; they can be synthesized de novo from plasma free fatty acids (FFA) or generated...