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Agnete Dyssegaard

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Recent Articles
1.
Magnussen J, Ettrup A, Lehel S, Peters D, Dyssegaard A, Thomsen M, et al.
Front Neuroimaging . 2024 Apr; 3:1358221. PMID: 38601007
The alpha7 nicotinic acetylcholine receptor (α7-nAChR) has has long been considered a promising therapeutic target for addressing cognitive impairments associated with a spectrum of neurological and psychiatric disorders, including Alzheimer's...
2.
Rasmussen A, Truchot N, Dyssegaard A, Fant P
Toxicol Pathol . 2023 Jul; 51(3):126-134. PMID: 37401471
In this study, we assessed the toxicity and toxicokinetics of racemic vigabatrin and its S- and R-enantiomers (vigabatrin consists of 50:50% of the two enantiomers) by administering doses of the...
3.
L Estrade E, Shalgunov V, Edgar F, Strebl-Bantillo M, Xiong M, Crestey F, et al.
J Labelled Comp Radiopharm . 2019 Nov; 63(2):46-55. PMID: 31674045
The serotonin 7 (5-HT ) receptor is suggested to be involved in a broad variety of CNS disorders, but very few in vivo tools exist to study this important target....
4.
Kramer V, Dyssegaard A, Flores J, Soza-Ried C, Rosch F, Knudsen G, et al.
Eur J Nucl Med Mol Imaging . 2019 Oct; 47(2):355-365. PMID: 31606832
Purpose: The serotonin receptor subtype 2A antagonist (5-HTR) (R)-[F]MH.MZ has in preclinical studies been identified as a promising PET imaging agent for quantification of cerebral 5-HTRs. It displays a very...
5.
Deen M, Hougaard A, Hansen H, Schain M, Dyssegaard A, Knudsen G, et al.
JAMA Neurol . 2019 May; 76(7):834-840. PMID: 31135819
Importance: Triptans, the most efficient acute treatment for migraine attacks, are 5-HT1B/1D receptor agonists, but their precise mechanism of action is not completely understood. The extent to which triptans enter...
6.
da Cunha-Bang S, Ettrup A, Mc Mahon B, Skibsted A, Schain M, Lehel S, et al.
Transl Psychiatry . 2019 Apr; 9(1):134. PMID: 30975977
Developing positron emission tomography (PET) radioligands for the detection of endogenous serotonin release will enable the investigation of serotonergic deficits in many neuropsychiatric disorders. The present study investigates how acute...
7.
Madsen M, Fisher P, Burmester D, Dyssegaard A, Stenbaek D, Kristiansen S, et al.
Neuropsychopharmacology . 2019 Mar; 44(7):1336-1337. PMID: 30846853
The original version of this article contained an error in the labelling of Figures 2 and 3. While the captions and figures themselves are correct, in order to correspond with...
8.
Madsen M, Fisher P, Burmester D, Dyssegaard A, Stenbaek D, Kristiansen S, et al.
Neuropsychopharmacology . 2019 Jan; 44(7):1328-1334. PMID: 30685771
The main psychedelic component of magic mushrooms is psilocybin, which shows promise as a treatment for depression and other mental disorders. Psychedelic effects are believed to emerge through stimulation of...
9.
Hansen H, Constantinescu C, Barret O, Herth M, Magnussen J, Lehel S, et al.
J Labelled Comp Radiopharm . 2018 Nov; 62(1):34-42. PMID: 30414212
So far, no suitable 5-HT R radioligand exists for clinical positron emission tomography (PET) imaging. [ F]2FP3 was first tested in vivo in cats, and the results were promising for...
10.
Feng L, Jensen P, Thomsen G, Dyssegaard A, Svarer C, Knudsen L, et al.
J Nucl Med . 2017 Jun; 58(6):989-995. PMID: 28572290
I-CLINDE is a radiotracer developed for SPECT and targets the 18-kDa translocator protein (TSPO). TSPO is upregulated in glial cells and used as a measure of neuroinflammation in a variety...