Agnes C L Martin
Overview
Explore the profile of Agnes C L Martin including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
698
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0
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Recent Articles
1.
Turnbull A, Ioannidis S, Krajewski W, Pinto-Fernandez A, Heride C, Martin A, et al.
Nature
. 2017 Oct;
550(7677):481-486.
PMID: 29045389
Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and their inhibition can induce the degradation of...
2.
Tisi D, Chiarparin E, Tamanini E, Pathuri P, Coyle J, Hold A, et al.
ACS Chem Biol
. 2016 Aug;
11(11):3093-3105.
PMID: 27571355
The members of the NSD subfamily of lysine methyl transferases are compelling oncology targets due to the recent characterization of gain-of-function mutations and translocations in several hematological cancers. To date,...
3.
Woolford A, Pero J, Aravapalli S, Berdini V, Coyle J, Day P, et al.
J Med Chem
. 2016 May;
59(11):5356-67.
PMID: 27167608
Elevated levels of human lipoprotein-associated phospholipase A2 (Lp-PLA2) are associated with cardiovascular disease and dementia. A fragment screen was conducted against Lp-PLA2 in order to identify novel inhibitors. Multiple fragment...
4.
Howard S, Amin N, Benowitz A, Chiarparin E, Cui H, Deng X, et al.
ACS Med Chem Lett
. 2014 Jun;
4(12):1208-12.
PMID: 24900632
Herein we describe the application of fragment-based drug design to bacterial DNA ligase. X-ray crystallography was used to guide structure-based optimization of a fragment-screening hit to give novel, nanomolar, AMP-competitive...
5.
Chaneton B, Hillmann P, Zheng L, Martin A, Maddocks O, Chokkathukalam A, et al.
Nature
. 2012 Oct;
491(7424):458-462.
PMID: 23064226
Cancer cells exhibit several unique metabolic phenotypes that are critical for cell growth and proliferation. Specifically, they overexpress the M2 isoform of the tightly regulated enzyme pyruvate kinase (PKM2), which...
6.
Martin A, Willoughby D, Ciruela A, Ayling L, Pagano M, Wachten S, et al.
Mol Pharmacol
. 2009 Jan;
75(4):830-42.
PMID: 19171672
Capacitative Ca(2+) entry (CCE), which occurs through the plasma membrane as a result of Ca(2+) store depletion, is mediated by stromal interacting molecule 1 (STIM1), a sensor of intracellular Ca(2+)...
7.
Martin A, Cooper D
Mol Pharmacol
. 2006 May;
70(2):769-77.
PMID: 16723496
Although the molecular identity of capacitative Ca(2+) entry (CCE) channels remains elusive, transient receptor potential channel (TRPC) family members 3, 6, and 7, which are activated by diacylglycerol (DAG), have...
8.
Wrigley J, Schurov I, Nunn E, Martin A, Clarke E, Ellis S, et al.
J Biol Chem
. 2004 Dec;
280(13):12523-35.
PMID: 15613471
Presenilins appear to form the active center of gamma-secretase but require the presence of the integral membrane proteins nicastrin, anterior pharynx defective 1, and presenilin enhancer 2 for catalytic function....
9.
Beher D, Clarke E, Wrigley J, Martin A, Nadin A, Churcher I, et al.
J Biol Chem
. 2004 Aug;
279(42):43419-26.
PMID: 15304503
Gamma-secretase is a multi-component enzyme complex that performs an intramembranous cleavage, releasing amyloid-beta (Abeta) peptides from processing intermediates of the beta-amyloid precursor protein. Because Abeta peptides are thought to be...