Agatheeswaran Subramaniam
Overview
Explore the profile of Agatheeswaran Subramaniam including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
159
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0
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Recent Articles
1.
Rydstrom A, Grahn T, Niroula A, Mansell E, van der Garde M, Pertesi M, et al.
Exp Hematol
. 2023 Sep;
127:40-51.
PMID: 37666355
Hematopoietic stem cells (HSCs) enable hematopoietic stem cell transplantation (HCT) through their ability to replenish the entire blood system. Proliferation of HSCs is linked to decreased reconstitution potential, and a...
2.
Safaee Talkhoncheh M, Baudet A, Ek F, Subramaniam A, Kao Y, Miharada N, et al.
Blood Adv
. 2023 Jul;
7(24):7407-7417.
PMID: 37487020
Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. To elucidate regulatory mechanisms governing the maintenance and propagation of human HSCs...
3.
Zemaitis K, Ghosh S, Hansson J, Subramaniam A
J Biol Chem
. 2023 Mar;
299(5):104662.
PMID: 36997086
To chemically modulate the ubiquitin-proteasome system for the degradation of specific target proteins is currently emerging as an alternative therapeutic modality. Earlier, we discovered such properties of the stem cell-supporting...
4.
Backstrom A, Yudovich D, Zemaitis K, Nilsen Falck L, Subramaniam A, Larsson J
Sci Rep
. 2022 Oct;
12(1):18169.
PMID: 36307542
The CRISPR/Cas9 system offers enormous versatility for functional genomics but many applications have proven to be challenging in primary human cells compared to cell lines or mouse cells. Here, to...
5.
Zemaitis K, Subramaniam A, Galeev R, Prosz A, Jassinskaja M, Hansson J, et al.
Exp Hematol
. 2022 Aug;
115:20-29.
PMID: 36041657
The molecular mechanisms regulating key fate decisions of hematopoietic stem cells (HSCs) remain incompletely understood. Here, we targeted global shRNA libraries to primary human hematopoietic stem and progenitor cells (HSPCs)...
6.
Subramaniam A, Sanden C, Moura-Castro L, Zemaitis K, Schmiderer L, Baudet A, et al.
Haematologica
. 2022 May;
107(9):2271-2275.
PMID: 35638550
No abstract available.
7.
Yudovich D, Backstrom A, Schmiderer L, Zemaitis K, Subramaniam A, Larsson J
Sci Rep
. 2020 Dec;
10(1):22393.
PMID: 33372184
The CRISPR/Cas9 system is a versatile tool for functional genomics and forward genetic screens in mammalian cells. However, it has been challenging to deliver the CRISPR components to sensitive cell...
8.
Schmiderer L, Subramaniam A, Zemaitis K, Backstrom A, Yudovich D, Soboleva S, et al.
Proc Natl Acad Sci U S A
. 2020 Aug;
117(35):21267-21273.
PMID: 32817519
Introduction of exogenous genetic material into primary stem cells is essential for studying biological function and for clinical applications. Traditional delivery methods for nucleic acids, such as electroporation, have advanced...
9.
Subramaniam A, Zemaitis K, Safaee Talkhoncheh M, Yudovich D, Backstrom A, Debnath S, et al.
Blood
. 2020 Jun;
136(19):2151-2161.
PMID: 32582923
Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. Here, we report that inhibition of the epigenetic regulator lysine-specific histone demethylase...
10.
Kumar P, Beck D, Galeev R, Thoms J, Safaee Talkhoncheh M, de Jong I, et al.
Blood Adv
. 2019 Feb;
3(4):681-691.
PMID: 30808686
Identification of determinants of fate choices in hematopoietic stem cells (HSCs) is essential to improve the clinical use of HSCs and to enhance our understanding of the biology of normal...