Afshan McCarthy
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Explore the profile of Afshan McCarthy including associated specialties, affiliations and a list of published articles.
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41
Citations
2512
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Recent Articles
1.
Brumm A, McCarthy A, Gerri C, Fallesen T, Woods L, McMahon R, et al.
Dev Cell
. 2024 Nov;
60(2):174-185.e5.
PMID: 39561779
The human blastocyst contains the pluripotent epiblast from which human embryonic stem cells (hESCs) can be derived. ACTIVIN/NODAL signaling maintains expression of the transcription factor NANOG and in vitro propagation...
2.
Iyer D, Khoei H, van der Weijden V, Kagawa H, Pradhan S, Novatchkova M, et al.
Cell
. 2024 Sep;
187(23):6566-6583.e22.
PMID: 39332412
Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is achieved by decreasing the activity of the...
3.
Balestrini P, Abdelbaki A, McCarthy A, Devito L, Senner C, Chen A, et al.
Development
. 2024 Sep;
151(17).
PMID: 39250534
During the first week of development, human embryos form a blastocyst composed of an inner cell mass and trophectoderm (TE) cells, the latter of which are progenitors of placental trophoblast....
4.
Alanis-Lobato G, Bartlett T, Huang Q, Simon C, McCarthy A, Elder K, et al.
Life Sci Alliance
. 2023 Oct;
7(1).
PMID: 37879938
Recent advances in single-cell omics have transformed characterisation of cell types in challenging-to-study biological contexts. In contexts with limited single-cell samples, such as the early human embryo inference of transcription...
5.
Gerri C, McCarthy A, Mei Scott G, Regin M, Stamatiadis P, Brumm S, et al.
Development
. 2023 Mar;
150(8).
PMID: 36971487
Our understanding of the molecular events driving cell specification in early mammalian development relies mainly on mouse studies, and it remains unclear whether these mechanisms are conserved across mammals, including...
6.
Lea R, McCarthy A, Boeing S, Fallesen T, Elder K, Snell P, et al.
Development
. 2021 Oct;
148(22).
PMID: 34661235
Current knowledge of the transcriptional regulation of human pluripotency is incomplete, with lack of interspecies conservation observed. Single-cell transcriptomics analysis of human embryos previously enabled us to identify transcription factors,...
7.
Bower O, McCarthy A, Lea R, Alanis-Lobato G, Zohren J, Gerri C, et al.
Curr Protoc
. 2021 Aug;
1(8):e232.
PMID: 34432381
CRISPR-Cas9 mutagenesis facilitates the investigation of gene function in a number of developmental and cellular contexts. Human pluripotent stem cells (hPSCs), either embryonic or induced, are a tractable cellular model...
8.
Alanis-Lobato G, Zohren J, McCarthy A, Fogarty N, Kubikova N, Hardman E, et al.
Proc Natl Acad Sci U S A
. 2021 May;
118(22).
PMID: 34050011
CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the correction of disease-associated alleles in somatic cells. The use of this approach has also been discussed in...
9.
Ruis P, Van Ly D, Borel V, Kafer G, McCarthy A, Howell S, et al.
Nature
. 2020 Nov;
589(7840):103-109.
PMID: 33239783
Mammalian telomeres protect chromosome ends from aberrant DNA repair. TRF2, a component of the telomere-specific shelterin protein complex, facilitates end protection through sequestration of the terminal telomere repeat sequence within...
10.
Gerri C, McCarthy A, Alanis-Lobato G, Demtschenko A, Bruneau A, Loubersac S, et al.
Nature
. 2020 Sep;
587(7834):443-447.
PMID: 32968278
Current understandings of cell specification in early mammalian pre-implantation development are based mainly on mouse studies. The first lineage differentiation event occurs at the morula stage, with outer cells initiating...