Aengus Stewart
Overview
Explore the profile of Aengus Stewart including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
35
Citations
9442
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Turajlic S, Xu H, Litchfield K, Rowan A, Horswell S, Chambers T, et al.
Cell
. 2018 Apr;
173(3):595-610.e11.
PMID: 29656894
The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective...
12.
Mitchell T, Turajlic S, Rowan A, Nicol D, Farmery J, OBrien T, et al.
Cell
. 2018 Apr;
173(3):611-623.e17.
PMID: 29656891
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies...
13.
Abbosh C, Birkbak N, Wilson G, Jamal-Hanjani M, Constantin T, Salari R, et al.
Nature
. 2017 Dec;
554(7691):264.
PMID: 29258292
This corrects the article DOI: 10.1038/nature22364.
14.
Di Tullio A, Rouault-Pierre K, Abarrategi A, Mian S, Grey W, Gribben J, et al.
Nat Commun
. 2017 Nov;
8(1):1679.
PMID: 29162833
Cytarabine (AraC) represents the most effective single agent treatment for AML. Nevertheless, overriding AraC resistance in AML remains an unmet medical need. Here we show that the CHK1 inhibitor (CHK1i)...
15.
Abbosh C, Birkbak N, Wilson G, Jamal-Hanjani M, Constantin T, Salari R, et al.
Nature
. 2017 Apr;
545(7655):446-451.
PMID: 28445469
The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour...
16.
Jamal-Hanjani M, Wilson G, McGranahan N, Birkbak N, Watkins T, Veeriah S, et al.
N Engl J Med
. 2017 Apr;
376(22):2109-2121.
PMID: 28445112
Background: Among patients with non-small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate intratumor heterogeneity...
17.
Esnault C, Gualdrini F, Horswell S, Kelly G, Stewart A, East P, et al.
Mol Cell
. 2017 Mar;
65(6):1081-1095.e5.
PMID: 28286024
We investigated the relationship among ERK signaling, histone modifications, and transcription factor activity, focusing on the ERK-regulated ternary complex factor family of SRF partner proteins. In MEFs, activation of ERK...
18.
Williamson L, Saponaro M, Boeing S, East P, Mitter R, Kantidakis T, et al.
Cell
. 2017 Feb;
168(5):843-855.e13.
PMID: 28215706
The transcription-related DNA damage response was analyzed on a genome-wide scale with great spatial and temporal resolution. Upon UV irradiation, a slowdown of transcript elongation and restriction of gene activity...
19.
Coda D, Gaarenstroom T, East P, Patel H, Miller D, Lobley A, et al.
Elife
. 2017 Feb;
6.
PMID: 28191871
NODAL/Activin signaling orchestrates key processes during embryonic development via SMAD2. How SMAD2 activates programs of gene expression that are modulated over time however, is not known. Here we delineate the...
20.
Lopez-Garcia C, Sansregret L, Domingo E, McGranahan N, Hobor S, Birkbak N, et al.
Cancer Cell
. 2017 Jan;
31(1):79-93.
PMID: 28073006
Chromosomal instability (CIN) contributes to cancer evolution, intratumor heterogeneity, and drug resistance. CIN is driven by chromosome segregation errors and a tolerance phenotype that permits the propagation of aneuploid genomes....