Adwait Amod Sathe
Overview
Explore the profile of Adwait Amod Sathe including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
351
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0
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Recent Articles
1.
Garg A, Keng W, Chen Z, Sathe A, Xing C, Kailasam P, et al.
J Clin Invest
. 2022 Oct;
132(23).
PMID: 36282599
Multiple genetic loci have been reported for progeroid syndromes. However, the molecular defects in some extremely rare forms of progeria have yet to be elucidated. Here, we report a 21-year-old...
2.
Guo G, Gong K, Beckley N, Zhang Y, Yang X, Chkheidze R, et al.
Nat Cell Biol
. 2022 Aug;
24(8):1291-1305.
PMID: 35915159
The epidermal growth factor receptor (EGFR) is a prime oncogene that is frequently amplified in glioblastomas. Here we demonstrate a new tumour-suppressive function of EGFR in EGFR-amplified glioblastomas regulated by...
3.
Liu Y, Sathe A, Abdullah K, McBrayer S, Adams S, Brenner A, et al.
Acta Neuropathol Commun
. 2022 Mar;
10(1):32.
PMID: 35264242
Diffusely infiltrating gliomas are among the most common central nervous system tumors in adults. Over the past decade, the subcategorization of these tumors has changed to include both traditional histologic...
4.
Xu H, Zhang S, Sathe A, Jin Z, Guan J, Sun W, et al.
Front Immunol
. 2022 Feb;
13:835986.
PMID: 35185928
During mechanical force-induced alveolar bone remodeling, macrophage-mediated local inflammation plays a critical role. Yet, the detailed heterogeneity of macrophages is still unknown. Single-cell RNA sequencing was used to study the...
5.
Richardson T, Sathe A, Xing C, Mirchia K, Viapiano M, Snuderl M, et al.
J Neuropathol Exp Neurol
. 2021 Mar;
80(4):354-365.
PMID: 33755138
Chromosomal instability due to mutations in genes guarding the stability of the genome is a well-known mechanism underlying tumorigenesis and malignant progression in numerous cancers. The effect of this process...
6.
Gong K, Guo G, Panchani N, Bender M, Gerber D, Minna J, et al.
Nat Cancer
. 2020 Dec;
1(4):394-409.
PMID: 33269343
EGFR inhibition is an effective treatment in the minority of non-small cell lung cancer (NSCLC) cases harboring EGFR-activating mutations, but not in EGFR wild type (EGFRwt) tumors. Here, we demonstrate...
7.
Suresh S, Chen B, Zhu J, Golden R, Lu C, Evers B, et al.
Nat Cancer
. 2020 Sep;
1(5):533-545.
PMID: 32984844
Cancer cells express high levels of PD-L1, a ligand of the PD-1 receptor on T cells, allowing tumors to suppress T cell activity. Clinical trials utilizing antibodies that disrupt the...
8.
Wang X, Sathe A, Smith G, Ruf-Zamojski F, Nair V, Lavine K, et al.
Proc Natl Acad Sci U S A
. 2020 Aug;
117(34):20729-20740.
PMID: 32796104
Tissue-resident macrophages can originate from embryonic or adult hematopoiesis. They play important roles in a wide range of biological processes including tissue remodeling during organogenesis, organ homeostasis, repair following injury,...
9.
Galbraith K, Kumar A, Abdullah K, Walker J, Adams S, Prior T, et al.
J Neuropathol Exp Neurol
. 2020 Jul;
79(8):843-854.
PMID: 32647886
IDH-wildtype glioblastoma is a relatively common malignant brain tumor in adults. These patients generally have dismal prognoses, although outliers with long survival have been noted in the literature. Recently, it...
10.
Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer
Huang H, Zhang Y, Gallegos V, Sorrelle N, Zaid M, Toombs J, et al.
EMBO Mol Med
. 2019 Oct;
11(11):e10515.
PMID: 31609088
TGFβ is important during pancreatic ductal adenocarcinoma (PDA) progression. Canonical TGFβ signaling suppresses epithelial pancreatic cancer cell proliferation; as a result, inhibiting TGFβ has not been successful in PDA. In...