Timothy E Richardson
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Explore the profile of Timothy E Richardson including associated specialties, affiliations and a list of published articles.
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90
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1003
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Recent Articles
1.
Convolutional Neural Networks for the segmentation of hippocampal structures in postmortem MRI scans
B N A, Li K, Honnorat N, Rashid T, Wang D, Li J, et al.
J Neurosci Methods
. 2025 Jan;
415():110359.
PMID: 39755177
Background: The hippocampus plays a crucial role in memory and is one of the first structures affected by Alzheimer's disease. Postmortem MRI offers a way to quantify the alterations by...
2.
Richardson T, Orr M, Orr T, Rohde S, Ehrenberg A, Thorn E, et al.
Alzheimers Dement
. 2024 Dec;
21(2):e14487.
PMID: 39737785
Introduction: Alzheimer's disease (AD), primary age-related tauopathy (PART), and chronic traumatic encephalopathy (CTE) all feature hyperphosphorylated tau (p-tau)-immunoreactive neurofibrillary degeneration, but differ in neuroanatomical distribution and progression of neurofibrillary degeneration...
3.
Hiya S, Maldonado-Diaz C, Rohde S, Gonzales M, Canbeldek L, Kulumani Mahadevan L, et al.
J Neuropathol Exp Neurol
. 2024 Dec;
84(3):177-194.
PMID: 39728026
Although Alzheimer disease neuropathologic change (ADNC) is the most common pathology underlying clinical dementia, the presence of multiple comorbid neuropathologies is increasingly being recognized as a major contributor to the...
4.
Hicks W, Gattie L, Shami M, Traylor J, Davar D, Najjar Y, et al.
Sci Rep
. 2024 Oct;
14(1):24843.
PMID: 39438602
Despite advances in the treatment paradigm for patients with metastatic melanoma, melanoma brain metastasis (MBM) continues to represent a significant treatment challenge. The study of MBM is limited, in part,...
5.
Richardson T, Walker J, Hambardzumyan D, Brem S, Hatanpaa K, Viapiano M, et al.
Acta Neuropathol
. 2024 Jul;
148(1):5.
PMID: 39012509
In recent years, the classification of adult-type diffuse gliomas has undergone a revolution, wherein specific molecular features now represent defining diagnostic criteria of IDH-wild-type glioblastomas, IDH-mutant astrocytomas, and IDH-mutant 1p/19q-codeleted...
6.
Maldonado-Diaz C, Hiya S, Yokoda R, Farrell K, Marx G, Kauffman J, et al.
Acta Neuropathol
. 2024 Mar;
147(1):58.
PMID: 38520489
Neurodegenerative pathologies such as Alzheimer disease neuropathologic change (ADNC), Lewy body disease (LBD), limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC), and cerebrovascular disease (CVD) frequently coexist, but little is known...
7.
Hiya S, Maldonado-Diaz C, Walker J, Richardson T
J Neuropathol Exp Neurol
. 2023 Nov;
83(1):2-10.
PMID: 37966908
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is a neuropathologic entity characterized by transactive response DNA-binding protein of 43-kDa (TDP-43)-immunoreactive inclusions that originate in the amygdala and then progress to...
8.
Marx G, Kauffman J, McKenzie A, Koenigsberg D, McMillan C, Morgello S, et al.
Acta Neuropathol
. 2023 Oct;
146(6):785-802.
PMID: 37815677
Understanding age acceleration, the discordance between biological and chronological age, in the brain can reveal mechanistic insights into normal physiology as well as elucidate pathological determinants of age-related functional decline...
9.
Walker J, Orr M, Orr T, Thorn E, Christie T, Yokoda R, et al.
Alzheimers Dement
. 2023 Oct;
20(2):783-797.
PMID: 37777848
Introduction: Alzheimer's disease (AD) and primary age-related tauopathy (PART) both harbor 3R/4R hyperphosphorylated-tau (p-tau)-positive neurofibrillary tangles (NFTs) but differ in the spatial p-tau development in the hippocampus. Methods: Using Nanostring...
10.
Richardson T, Yokoda R, Rashidipour O, Vij M, Snuderl M, Brem S, et al.
Neurooncol Adv
. 2023 Aug;
5(1):vdad085.
PMID: 37554222
Background: Mutations in mismatch repair (MMR) genes (, , , and are associated with microsatellite instability and a hypermutator phenotype in numerous systemic cancers, and germline MMR mutations have been...