Adrienne L Edkins
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Explore the profile of Adrienne L Edkins including associated specialties, affiliations and a list of published articles.
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56
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857
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Recent Articles
1.
Daub C, Michaels A, Mabate B, Mkabayi L, Edkins A, Pletschke B
Molecules
. 2025 Mar;
30(5).
PMID: 40076378
Obesity and type 2 diabetes mellitus (T2DM) are major health concerns worldwide, often managed with treatments that have significant limitations and side effects. This study examines the potential of sodium...
2.
Okpara M, Vaaltyn M, Watson J, Alhassan M, Albericio F, de la Torre B, et al.
ACS Infect Dis
. 2024 Oct;
10(11):3853-3867.
PMID: 39475219
The central role of the chaperome in maintaining cellular proteostasis has seen numerous viral families evolve to parasitically exploit host chaperones in their life cycle. The HSP90 chaperone protein and...
3.
Mathenjwa G, Chakraborty A, Chakraborty A, Muller R, Akerman M, Bode M, et al.
RSC Med Chem
. 2024 Sep;
PMID: 39290382
Despite Hsp90's well documented promise as a target for developing cancer chemotherapeutics, its inhibitors have struggled to progress through clinical trials. This is, in part, attributed to the cytoprotective compensatory...
4.
Discovery of a small-molecule inhibitor of KSHV lytic replication from the MMV pandemic response box
Okpara M, Weaver F, Whitehouse A, Veale C, Edkins A
Antiviral Res
. 2024 Aug;
230:105990.
PMID: 39154751
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent for primary effusion lymphoma (PEL), multicentric Castleman's disease (MCD) and Kaposi's sarcoma (KS). KSHV is one of the oncoviruses that contribute to...
5.
Veale C, Chakraborty A, Mhlanga R, Albericio F, de la Torre B, Edkins A, et al.
Chem Commun (Camb)
. 2024 May;
60(45):5844-5847.
PMID: 38752317
Native mass spectrometric analysis of TPR2A and GrpE with unpurified peptides derived from limited proteolysis of their respective PPI partners (HSP90 C-terminus and DnaK) facilitated efficient, qualitative identification of interfacial...
6.
Mayer M, Blair L, Blatch G, Borges T, Chadli A, Chiosis G, et al.
Cell Stress Chaperones
. 2024 Feb;
29(1):143-157.
PMID: 38311120
Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance...
7.
Bourboulia D, Blair L, Clark M, Edkins A, Hightower L, Mollapour M, et al.
Cell Stress Chaperones
. 2024 Feb;
29(1):113-115.
PMID: 38309687
No abstract available.
8.
Ramatsui L, Sithole T, Gandla M, Jonsson L, Edkins A, Malgas S, et al.
J Anim Physiol Anim Nutr (Berl)
. 2024 Jan;
108(3):596-610.
PMID: 38169048
Xylanases from glycoside hydrolase (GH) families 10 and 11 are common feed additives for broiler chicken diets due to their catalytic activity on the nonstarch polysaccharide xylan. This study investigated...
9.
Jamabo M, Mahlalela M, Edkins A, Boshoff A
Int J Mol Sci
. 2023 Aug;
24(15).
PMID: 37569903
Human African trypanosomiasis is a neglected tropical disease caused by the extracellular protozoan parasite , and targeted for eradication by 2030. The COVID-19 pandemic contributed to the lengthening of the...
10.
Tonui R, John R, Edkins A
Methods Mol Biol
. 2023 Aug;
2693:113-123.
PMID: 37540431
Many molecular chaperones act as holdases by binding hydrophobic regions of substrates to prevent aggregation. Therefore, measuring holdase activity is an amenable method to determine chaperone activity. The holdase function...