Adrienne E Swanstrom
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Explore the profile of Adrienne E Swanstrom including associated specialties, affiliations and a list of published articles.
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14
Citations
302
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Recent Articles
1.
Coren L, Trivett M, Welker J, Thomas J, Gorelick R, Kose E, et al.
PLoS One
. 2025 Jan;
20(1):e0314751.
PMID: 39787126
T cell immunotherapy success is dependent on effective levels of antigen receptor expressed at the surface of engineered cells. Efforts to optimize surface expression in T cell receptor (TCR)-based therapeutic...
2.
Swanstrom A, Gorelick R, Welker J, Schmidt F, Lu B, Wang K, et al.
EBioMedicine
. 2023 Aug;
95:104764.
PMID: 37625266
Background: Long-acting subcutaneous lenacapavir (LEN), a first-in-class HIV capsid inhibitor approved by the US FDA for the treatment of multidrug-resistant HIV-1 with twice yearly dosing, is under investigation for HIV-1...
3.
Welles H, King H, Nettey L, Cavett N, Gorman J, Zhou T, et al.
PLoS Pathog
. 2022 Jun;
18(6):e1010574.
PMID: 35709309
Both SIV and SHIV are powerful tools for evaluating antibody-mediated prevention and treatment of HIV-1. However, owing to a lack of rhesus-derived SIV broadly neutralizing antibodies (bnAbs), testing of bnAbs...
4.
Swanstrom A, Immonen T, Oswald K, Pyle C, Thomas J, Bosche W, et al.
J Clin Invest
. 2021 Jan;
131(6).
PMID: 33465055
The effectiveness of virus-specific strategies, including administered HIV-specific mAbs, to target cells that persistently harbor latent, rebound-competent HIV genomes during combination antiretroviral therapy (cART) has been limited by inefficient induction...
5.
Khanal S, Fennessey C, OBrien S, Thorpe A, Reid C, Immonen T, et al.
J Virol
. 2019 Oct;
94(1).
PMID: 31597757
Genetically barcoded viral populations are powerful tools for evaluating the overall viral population structure as well as assessing the dynamics and evolution of individual lineages over time. Barcoded viruses are...
6.
Trivett M, Burke J, Deleage C, Coren L, Hill B, Jain S, et al.
J Virol
. 2019 Aug;
93(21).
PMID: 31434738
doptive ell ransfer (ACT) is a powerful experimental approach to directly study T-cell-mediated immunity In the rhesus macaque AIDS virus model, infusing simian immunodeficiency virus (SIV)-infected animals with CD8 T...
7.
Ferris A, Wells D, Guo S, Del Prete G, Swanstrom A, Coffin J, et al.
PLoS Pathog
. 2019 Jul;
15(7):e1007869.
PMID: 31291371
Clonal expansion of HIV infected cells plays an important role in the formation and persistence of the reservoir that allows the virus to persist, in DNA form, despite effective antiretroviral...
8.
OBrien S, Swanstrom A, Pegu A, Ko S, Immonen T, Del Prete G, et al.
PLoS Pathog
. 2019 Apr;
15(4):e1007632.
PMID: 30943274
Chimeric Simian-Human Immunodeficiency Viruses (SHIVs) are an important tool for evaluating anti-HIV Env interventions in nonhuman primate (NHP) models. However, most unadapted SHIVs do not replicate well in vivo limiting...
9.
Swanstrom A, Jacques A, Del Prete G, Bieniasz P, Hatziioannou T, Gorelick R, et al.
AIDS Res Hum Retroviruses
. 2019 Jan;
35(5):473-476.
PMID: 30632394
Persistence of replication-competent viral reservoirs during infection remains a barrier to HIV cure, despite the ability of combination antiretroviral therapy (cART) to effectively suppress viral replication. Simian-tropic HIV (stHIV) is...
10.
Swanstrom A, Gorelick R, Wu G, Howell B, Vijayagopalan A, Shoemaker R, et al.
AIDS Res Hum Retroviruses
. 2018 Jun;
34(11):993-1001.
PMID: 29869527
Although effective for suppressing viral replication, combination antiretroviral treatment (cART) does not represent definitive therapy for HIV infection due to persistence of replication-competent viral reservoirs. The advent of effective cART...