Adriana Gambardella
Overview
Explore the profile of Adriana Gambardella including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
1330
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0
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Recent Articles
1.
Meng Y, Carrelha J, Drissen R, Ren X, Zhang B, Gambardella A, et al.
Nat Cell Biol
. 2023 May;
25(6):812-822.
PMID: 37127714
Haematopoietic stem cells (HSCs) are multipotent, but individual HSCs can show restricted lineage output in vivo. Currently, the molecular mechanisms and physiological role of HSC fate restriction remain unknown. Here...
2.
Carrelha J, Meng Y, Kettyle L, Luis T, Norfo R, Alcolea V, et al.
Nature
. 2018 Jan;
554(7690):106-111.
PMID: 29298288
Rare multipotent haematopoietic stem cells (HSCs) in adult bone marrow with extensive self-renewal potential can efficiently replenish all myeloid and lymphoid blood cells, securing long-term multilineage reconstitution after physiological and...
3.
Hoppe P, Schwarzfischer M, Loeffler D, Kokkaliaris K, Hilsenbeck O, Moritz N, et al.
Nature
. 2016 Jul;
535(7611):299-302.
PMID: 27411635
The mechanisms underlying haematopoietic lineage decisions remain disputed. Lineage-affiliated transcription factors with the capacity for lineage reprogramming, positive auto-regulation and mutual inhibition have been described as being expressed in uncommitted...
4.
Drissen R, Buza-Vidas N, Woll P, Thongjuea S, Gambardella A, Giustacchini A, et al.
Nat Immunol
. 2016 Apr;
17(6):666-676.
PMID: 27043410
According to current models of hematopoiesis, lymphoid-primed multi-potent progenitors (LMPPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)Flt3(hi)) and common myeloid progenitors (CMPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)CD41(hi)) establish an early branch point for separate lineage-commitment pathways from hematopoietic stem cells,...
5.
Grover A, Sanjuan-Pla A, Thongjuea S, Carrelha J, Giustacchini A, Gambardella A, et al.
Nat Commun
. 2016 Mar;
7:11075.
PMID: 27009448
Aged haematopoietic stem cells (HSCs) generate more myeloid cells and fewer lymphoid cells compared with young HSCs, contributing to decreased adaptive immunity in aged individuals. However, it is not known...
6.
Sanjuan-Pla A, Macaulay I, Jensen C, Woll P, Luis T, Mead A, et al.
Nature
. 2013 Aug;
502(7470):232-6.
PMID: 23934107
The blood system is maintained by a small pool of haematopoietic stem cells (HSCs), which are required and sufficient for replenishing all human blood cell lineages at millions of cells...
7.
Bird T, Lu W, Boulter L, Gordon-Keylock S, Ridgway R, Williams M, et al.
Proc Natl Acad Sci U S A
. 2013 Apr;
110(16):6542-7.
PMID: 23576749
Tissue progenitor cells are an attractive target for regenerative therapy. In various organs, bone marrow cell (BMC) therapy has shown promising preliminary results, but to date no definite mechanism has...
8.
Bereshchenko O, Mancini E, Luciani L, Gambardella A, Riccardi C, Nerlov C
Haematologica
. 2012 Feb;
97(9):1291-4.
PMID: 22371176
Pontin is a highly conserved DNA helicase/ATPase which is a component of several macromolecular complexes with functions that include DNA repair, telomere maintenance and tumor suppression. While Pontin is known...
9.
Ruffell D, Mourkioti F, Gambardella A, Kirstetter P, Lopez R, Rosenthal N, et al.
Proc Natl Acad Sci U S A
. 2009 Oct;
106(41):17475-80.
PMID: 19805133
Macrophages play an essential role in the resolution of tissue damage through removal of necrotic cells, thus paving the way for tissue regeneration. Macrophages also directly support the formation of...