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Adrian Zander

Explore the profile of Adrian Zander including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 224
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Recent Articles
1.
Willkomm S, Oellig C, Zander A, Restle T, Keegan R, Grohmann D, et al.
Nat Microbiol . 2017 Mar; 2:17035. PMID: 28319084
Argonaute (Ago) proteins in eukaryotes are known as key players in post-transcriptional gene silencing, while recent studies on prokaryotic Agos hint at their role in the protection against invading DNA....
2.
Zander A, Willkomm S, Ofer S, van Wolferen M, Egert L, Buchmeier S, et al.
Nat Microbiol . 2017 Mar; 2:17034. PMID: 28319081
Prokaryotic Argonaute proteins acquire guide strands derived from invading or mobile genetic elements, via an unknown pathway, to direct guide-dependent cleavage of foreign DNA. Here, we report that Argonaute from...
3.
Willkomm S, Zander A, Grohmann D
Methods Mol Biol . 2016 Dec; 1517:291-304. PMID: 27924490
Deciphering the molecular mechanisms of eukaryotic Argonaute proteins is crucial for the understanding of RNA interference (RNAi), a posttranscriptional gene silencing process. Fluorescence-based single-molecule studies like single-molecule Förster resonance energy...
4.
Willkomm S, Zander A, Grohmann D, Restle T
PLoS One . 2016 Oct; 11(10):e0164695. PMID: 27741323
Argonaute (Ago) proteins from all three domains of life are key players in processes that specifically regulate cellular nucleic acid levels. Some of these Ago proteins, among them human Argonaute2...
5.
Willkomm S, Zander A, Gust A, Grohmann D
Life (Basel) . 2015 Feb; 5(1):538-53. PMID: 25692904
Argonaute proteins can be found in all three domains of life. In eukaryotic organisms, Argonaute is, as the functional core of the RNA-silencing machinery, critically involved in the regulation of...
6.
Gust A, Zander A, Gietl A, Holzmeister P, Schulz S, Lalkens B, et al.
Molecules . 2014 Oct; 19(10):15824-65. PMID: 25271426
Single-molecule fluorescence techniques are ideally suited to provide information about the structure-function-dynamics relationship of a biomolecule as static and dynamic heterogeneity can be easily detected. However, what type of single-molecule...
7.
Zander A, Holzmeister P, Klose D, Tinnefeld P, Grohmann D
RNA Biol . 2014 Jan; 11(1):45-56. PMID: 24442234
Argonaute can be found in all three domains of life and is the functional core of the eukaryotic RNA-silencing machinery. In order to shed light on the conformational changes that...