Adrian S Culf
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Explore the profile of Adrian S Culf including associated specialties, affiliations and a list of published articles.
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13
Citations
201
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Recent Articles
1.
Culf A
Biopolymers
. 2019 May;
110(6):e23285.
PMID: 31070792
A review of molecular tools and sensors assembled on N-substituted glycine, or α-peptoid, oligomers between 2013 and November 2018 with the following sections: (a) Peptoids as crystal growth modifiers, (b)...
2.
Culf A, Yin H, Monro S, Ghosh A, Barnett D, Ouellette R, et al.
Bioorg Med Chem
. 2016 Jan;
24(5):929-37.
PMID: 26810709
Small-molecule fluorescent reporters of disease states are highly sought after, yet they remain elusive. Anthranilic acids are extremely sensitive environmental probes, and hold promise as general but selective agents for...
3.
Culf A, Cuperlovic-Culf M, Ouellette R, Decken A
Org Lett
. 2015 May;
17(11):2744-7.
PMID: 25990766
One-pot syntheses of fluorescent o-aminobenzoates, o-aminopyridine carboxylates, and a 2'-amino-[1,1'-biphenyl]-2-carboxylic acid are described. Carbodiimides are used as the source of the 2-amino function which inserts onto an aromatic ring using...
4.
Cuperlovic-Culf M, Touaibia M, St-Coeur P, Poitras J, Morin P, Culf A
Metabolites
. 2014 Sep;
4(3):807-30.
PMID: 25222834
Inhibition of protein deacetylation enzymes, alone or in combination with standard chemotherapies, is an exciting addition to cancer therapy. We have investigated the effect of deacetylase inhibition on the metabolism...
5.
Culf A, Cuperlovic-Culf M, Leger D, Decken A
Org Lett
. 2014 May;
16(10):2780-3.
PMID: 24797336
A convenient and efficient methodology for the head-to-tail macrocyclization of small 3-mer, 4-mer, and 5-mer α-peptoid acids (9-, 12-, and 15-atom N-substituted glycine oligomers) is described. The cyclic trimer has...
6.
Lefort N, Brown A, Lloyd V, Ouellette R, Touaibia M, Culf A, et al.
J Pharm Biomed Anal
. 2013 Oct;
93:77-85.
PMID: 24074721
Metabolomics analysis was used to determine the effect of two well known, non-proprietary metabolic modulators, dichloroacetate and allopurinol on breast cancer cell lines. Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor and...
7.
Culf A, Ouellette R
Molecules
. 2010 Aug;
15(8):5282-335.
PMID: 20714299
Peptoids (N-substituted polyglycines and extended peptoids with variant backbone amino-acid monomer units) are oligomeric synthetic polymers that are becoming a valuable molecular tool in the biosciences. Of particular interest are...
8.
Cuperlovic-Culf M, Barnett D, Culf A, Chute I
Drug Discov Today
. 2010 Jul;
15(15-16):610-21.
PMID: 20601091
Metabolomics represents a global quantitative assessment of metabolites within a biological system. The metabolic analysis of cell cultures has many potential applications and advantages to currently used methods for cell...
9.
Cuperlovic-Culf M, Belacel N, Culf A, Chute I, Ouellette R, Burton I, et al.
Magn Reson Chem
. 2009 Sep;
47 Suppl 1:S96-104.
PMID: 19731396
The global analysis of metabolites can be used to define the phenotypes of cells, tissues or organisms. Classifying groups of samples based on their metabolic profile is one of the...
10.
Culf A, Cuperlovic-Culf M, Laflamme M, Tardiff B, Ouellette R
Oligonucleotides
. 2008 Mar;
18(1):81-92.
PMID: 18321165
Fast methods for the removal of permanent amide exo-cyclic protective groups widely used in phosphoramidite-method DNA synthesis are desirable for many genomics and proteomics applications. In this communication, we present...