Adrian Manea
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Explore the profile of Adrian Manea including associated specialties, affiliations and a list of published articles.
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33
Citations
810
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Recent Articles
1.
Jakobsson G, Papareddy P, Andersson H, Mulholland M, Bhongir R, Ljungcrantz I, et al.
Crit Care
. 2023 Sep;
27(1):374.
PMID: 37773186
Background And Aims: The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current treatments. S100A8/A9 is a pro-inflammatory alarmin abundantly secreted by activated...
2.
Manea S, Vlad M, Lazar A, Muresian H, Simionescu M, Manea A
Antioxidants (Basel)
. 2022 Dec;
11(12).
PMID: 36552592
Dysregulated epigenetic mechanisms promote transcriptomic and phenotypic alterations in cardiovascular diseases. The role of histone methylation-related pathways in atherosclerosis is largely unknown. We hypothesize that lysine-specific demethylase 1A (LSD1/KDM1A) regulates...
3.
Lazar A, Vlad M, Manea A, Simionescu M, Manea S
Antioxidants (Basel)
. 2021 Sep;
10(9).
PMID: 34572988
Accumulating evidence implicates the histone acetylation-based epigenetic mechanisms in the pathoetiology of diabetes-associated micro-/macrovascular complications. Diabetic kidney disease (DKD) is a progressive chronic inflammatory microvascular disorder ultimately leading to glomerulosclerosis...
4.
Manea S, Vlad M, Rebleanu D, Lazar A, Fenyo I, Calin M, et al.
Oxid Med Cell Longev
. 2021 Mar;
2021:6685612.
PMID: 33763173
Excessive production of reactive oxygen species (ROS) and the ensuing oxidative stress are instrumental in all phases of atherosclerosis. Despite the major achievements in understanding the regulatory pathways and molecular...
5.
Manea S, Vlad M, Fenyo I, Lazar A, Raicu M, Muresian H, et al.
Redox Biol
. 2019 Oct;
28:101338.
PMID: 31634818
NADPH oxidase (Nox)-derived reactive oxygen species (ROS) are instrumental in all inflammatory phases of atherosclerosis. Dysregulated histone deacetylase (HDAC)-related epigenetic pathways have been mechanistically linked to alterations in gene expression...
6.
Vlad M, Manea S, Lazar A, Raicu M, Muresian H, Simionescu M, et al.
Oxid Med Cell Longev
. 2019 Oct;
2019:3201062.
PMID: 31565149
Histone acetylation plays a major role in epigenetic regulation of gene expression. Monocyte-derived macrophages express functional NADPH oxidase 5 (Nox5) that contributes to oxidative stress in atherogenesis. The mechanisms of...
7.
Hanf A, Oelze M, Manea A, Li H, Munzel T, Daiber A
Chem Biol Interact
. 2019 Sep;
313:108834.
PMID: 31545955
The anthracycline doxorubicin (DOX) is widely used in cancer therapy with the limitation of cardiotoxicity leading to the development of congestive heart failure. DOX-induced oxidative stress and changes of the...
8.
Manea S, Antonescu M, Fenyo I, Raicu M, Simionescu M, Manea A
Redox Biol
. 2018 Mar;
16:332-343.
PMID: 29587244
Reactive oxygen species (ROS) generated by up-regulated NADPH oxidase (Nox) contribute to structural-functional alterations of the vascular wall in diabetes. Epigenetic mechanisms, such as histone acetylation, emerged as important regulators...
9.
Manea S, Fenyo I, Manea A
Int J Biochem Cell Biol
. 2016 Apr;
75:123-30.
PMID: 27102411
Endothelin-1 (ET-1) plays an important role in the pathophysiology of diabetes-associated cardiovascular disorders. The molecular mechanisms leading to ET-1 upregulation in diabetes are not entirely defined. c-Src tyrosine kinase regulates...
10.
Aguado A, Fischer T, Rodriguez C, Manea A, Martinez-Gonzalez J, Touyz R, et al.
J Hypertens
. 2015 Dec;
34(2):253-65.
PMID: 26682942
Objective: NOX-1 and NOX-4 are key enzymes responsible for reactive oxygen species (ROS) generation in vascular smooth muscle cells (VSMC). The RNA-binding protein Hu antigen R (HuR) is implicated in...