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» Authors » Simona-Adriana Manea

Simona-Adriana Manea

Explore the profile of Simona-Adriana Manea including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 14
Citations 286
Followers 0
Related Specialties
Cell Biology
Endocrinology
Biochemistry
Top 10 Co-Authors
Adrian Manea
Maya Simionescu
Monica Raicu
Mihaela-Loredana Vlad
Ioana Madalina Fenyo
Alexandra-Gela Lazar
Horia Muresian
Andra Todirita
Shlomo Sasson
Alina Constantin
Published In
Redox Biol
Cell Tissue Res
Oxid Med Cell Longev
Biochem Biophys Res Commun
Antioxidants (Basel)
Affiliations
Soon will be listed here.
Recent Articles
1.
Pharmacological Inhibition of Lysine-Specific Demethylase 1A Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Deficient Mice by a Mechanism Involving Decreased Oxidative Stress and Inflammation; Potential Implications in Human...
Manea S, Vlad M, Lazar A, Muresian H, Simionescu M, Manea A
Antioxidants (Basel) . 2022 Dec; 11(12). PMID: 36552592
Dysregulated epigenetic mechanisms promote transcriptomic and phenotypic alterations in cardiovascular diseases. The role of histone methylation-related pathways in atherosclerosis is largely unknown. We hypothesize that lysine-specific demethylase 1A (LSD1/KDM1A) regulates...
2.
Activated Histone Acetyltransferase p300/CBP-Related Signalling Pathways Mediate Up-Regulation of NADPH Oxidase, Inflammation, and Fibrosis in Diabetic Kidney
Lazar A, Vlad M, Manea A, Simionescu M, Manea S
Antioxidants (Basel) . 2021 Sep; 10(9). PMID: 34572988
Accumulating evidence implicates the histone acetylation-based epigenetic mechanisms in the pathoetiology of diabetes-associated micro-/macrovascular complications. Diabetic kidney disease (DKD) is a progressive chronic inflammatory microvascular disorder ultimately leading to glomerulosclerosis...
3.
Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High-Resolution Near-Infrared Fluorescence Imaging Using VCAM-1-Targeted Liposomes Entrapping a Fluorogenic Redox-Sensitive Probe
Manea S, Vlad M, Rebleanu D, Lazar A, Fenyo I, Calin M, et al.
Oxid Med Cell Longev . 2021 Mar; 2021:6685612. PMID: 33763173
Excessive production of reactive oxygen species (ROS) and the ensuing oxidative stress are instrumental in all phases of atherosclerosis. Despite the major achievements in understanding the regulatory pathways and molecular...
4.
Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human...
Manea S, Vlad M, Fenyo I, Lazar A, Raicu M, Muresian H, et al.
Redox Biol . 2019 Oct; 28:101338. PMID: 31634818
NADPH oxidase (Nox)-derived reactive oxygen species (ROS) are instrumental in all inflammatory phases of atherosclerosis. Dysregulated histone deacetylase (HDAC)-related epigenetic pathways have been mechanistically linked to alterations in gene expression...
5.
Histone Acetyltransferase-Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential Mechanism of Reactive Oxygen Species Overproduction in Atherosclerosis
Vlad M, Manea S, Lazar A, Raicu M, Muresian H, Simionescu M, et al.
Oxid Med Cell Longev . 2019 Oct; 2019:3201062. PMID: 31565149
Histone acetylation plays a major role in epigenetic regulation of gene expression. Monocyte-derived macrophages express functional NADPH oxidase 5 (Nox5) that contributes to oxidative stress in atherogenesis. The mechanisms of...
6.
Epigenetic regulation of vascular NADPH oxidase expression and reactive oxygen species production by histone deacetylase-dependent mechanisms in experimental diabetes
Manea S, Antonescu M, Fenyo I, Raicu M, Simionescu M, Manea A
Redox Biol . 2018 Mar; 16:332-343. PMID: 29587244
Reactive oxygen species (ROS) generated by up-regulated NADPH oxidase (Nox) contribute to structural-functional alterations of the vascular wall in diabetes. Epigenetic mechanisms, such as histone acetylation, emerged as important regulators...
7.
c-Src tyrosine kinase mediates high glucose-induced endothelin-1 expression
Manea S, Fenyo I, Manea A
Int J Biochem Cell Biol . 2016 Apr; 75:123-30. PMID: 27102411
Endothelin-1 (ET-1) plays an important role in the pathophysiology of diabetes-associated cardiovascular disorders. The molecular mechanisms leading to ET-1 upregulation in diabetes are not entirely defined. c-Src tyrosine kinase regulates...
8.
Regulation of Nox enzymes expression in vascular pathophysiology: Focusing on transcription factors and epigenetic mechanisms
Manea S, Constantin A, Manda G, Sasson S, Manea A
Redox Biol . 2015 Jul; 5:358-366. PMID: 26133261
NADPH oxidases (Nox) represent a family of hetero-oligomeric enzymes whose exclusive biological function is the generation of reactive oxygen species (ROS). Nox-derived ROS are essential modulators of signal transduction pathways...
9.
Human monocytes and macrophages express NADPH oxidase 5; a potential source of reactive oxygen species in atherosclerosis
Manea A, Manea S, Gan A, Constantin A, Fenyo I, Raicu M, et al.
Biochem Biophys Res Commun . 2015 Apr; 461(1):172-9. PMID: 25871798
Monocytes (Mon) and Mon-derived macrophages (Mac) orchestrate important oxidative and inflammatory reactions in atherosclerosis by secreting reactive oxygen species (ROS) due, in large part, to the upregulated NADPH oxidases (Nox)....
10.
High-glucose-increased expression and activation of NADPH oxidase in human vascular smooth muscle cells is mediated by 4-hydroxynonenal-activated PPARα and PPARβ/δ
Manea A, Manea S, Todirita A, Albulescu I, Raicu M, Sasson S, et al.
Cell Tissue Res . 2015 Feb; 361(2):593-604. PMID: 25722086
High glucose induces vascular smooth muscle cell (SMC) dysfunction by generating oxidative stress attributable, in part, to the up-regulated NADPH oxidases (Nox). We have attempted to elucidate the high-glucose-generated molecular...