Adrian Jinich
Overview
Explore the profile of Adrian Jinich including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
269
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Recent Articles
1.
Mishra S, Singh P, Hu X, Lopez-Quezada L, Jinich A, Jahn R, et al.
Proc Natl Acad Sci U S A
. 2025 Mar;
122(10):e2425981122.
PMID: 40053362
(Mtb), a leading cause of death from infection, completes its life cycle entirely in humans except for transmission through the air. To begin to understand how Mtb survives aerosolization, we...
2.
Flamholz A, Goldford J, Richter P, Larsson E, Jinich A, W Fischer W, et al.
mSystems
. 2024 Sep;
9(10):e0076324.
PMID: 39230322
Aerobes require dioxygen (O) to grow; anaerobes do not. However, nearly all microbes-aerobes, anaerobes, and facultative organisms alike-express enzymes whose substrates include O, if only for detoxification. This presents a...
3.
Meade R, Long J, Jinich A, Rhee K, Ashbrook D, Williams R, et al.
G3 (Bethesda)
. 2023 Jul;
13(9).
PMID: 37405387
Genetic differences among mammalian hosts and among strains of Mycobacterium tuberculosis (Mtb) are well-established determinants of tuberculosis (TB) patient outcomes. The advent of recombinant inbred mouse panels and next-generation transposon...
4.
Meade R, Long J, Jinich A, Rhee K, Ashbrook D, Williams R, et al.
bioRxiv
. 2023 Mar;
PMID: 36945430
Genetic differences among mammalian hosts and ( ) strains determine diverse tuberculosis (TB) patient outcomes. The advent of recombinant inbred mouse panels and next-generation transposon mutagenesis and sequencing approaches has...
5.
Rappoport D, Jinich A
J Chem Inf Model
. 2023 Feb;
63(5):1637-1648.
PMID: 36802628
Compact and interpretable structural feature representations are required for accurately predicting properties and function of proteins. In this work, we construct and evaluate three-dimensional feature representations of protein structures based...
6.
Krenn M, Pollice R, Guo S, Aldeghi M, Cervera-Lierta A, Friederich P, et al.
Nat Rev Phys
. 2022 Oct;
4(12):761-769.
PMID: 36247217
An oracle that correctly predicts the outcome of every particle physics experiment, the products of every possible chemical reaction or the function of every protein would revolutionize science and technology....
7.
Harold L, Jinich A, Hards K, Cordeiro A, Keighley L, Cross A, et al.
J Biol Chem
. 2022 Mar;
298(5):101859.
PMID: 35337802
Oxidation of malate to oxaloacetate, catalyzed by either malate dehydrogenase (Mdh) or malate quinone oxidoreductase (Mqo), is a critical step of the tricarboxylic acid cycle. Both Mqo and Mdh are...
8.
Beites T, Jansen R, Wang R, Jinich A, Rhee K, Schnappinger D, et al.
Nat Commun
. 2021 Nov;
12(1):6593.
PMID: 34782606
The human pathogen Mycobacterium tuberculosis depends on host fatty acids as a carbon source. However, fatty acid β-oxidation is mediated by redundant enzymes, which hampers the development of antitubercular drugs...
9.
Jinich A, Sanchez-Lengeling B, Ren H, Goldford J, Noor E, Sanders J, et al.
Proc Natl Acad Sci U S A
. 2020 Dec;
117(52):32910-32918.
PMID: 33376214
Redox biochemistry plays a key role in the transduction of chemical energy in living systems. However, the compounds observed in metabolic redox reactions are a minuscule fraction of chemical space....
10.
Wytock T, Zhang M, Jinich A, Fiebig A, Crosson S, Motter A
Biophys J
. 2020 Oct;
119(10):2074-2086.
PMID: 33068537
Antagonistic interactions in biological systems, which occur when one perturbation blunts the effect of another, are typically interpreted as evidence that the two perturbations impact the same cellular pathway or...