Adrian J McNairn
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Explore the profile of Adrian J McNairn including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
656
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Recent Articles
1.
Iu D, Maya J, Vu L, Fogarty E, McNairn A, Ahmed F, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(50):e2415119121.
PMID: 39621903
Myalgic encephalomyelitis/chronic fatigue syndrome (ME) is a severe, debilitating disease, with substantial evidence pointing to immune dysregulation as a key contributor to pathophysiology. To characterize the gene regulatory state underlying...
2.
Watson N, Patel R, Kean C, Veazey J, Oyesola O, Laniewski N, et al.
Sci Immunol
. 2024 Feb;
9(92):eadf8776.
PMID: 38394230
CD8 T cells are classically recognized as adaptive lymphocytes based on their ability to recognize specific foreign antigens and mount memory responses. However, recent studies indicate that some antigen-inexperienced CD8...
3.
McNairn A, Chuang C, Bloom J, Wallace M, Schimenti J
Nature
. 2019 Feb;
567(7746):105-108.
PMID: 30787433
Genomic instability can trigger cellular responses that include checkpoint activation, senescence and inflammation. Although genomic instability has been extensively studied in cell culture and cancer paradigms, little is known about...
4.
McNairn A, Rinaldi V, Schimenti J
Genetics
. 2016 Dec;
205(2):529-537.
PMID: 27986806
The mammalian Mcm-domain containing 2 (Mcmdc2) gene encodes a protein of unknown function that is homologous to the minichromosome maintenance family of DNA replication licensing and helicase factors. Drosophila melanogaster...
5.
McNairn A, Brusadelli M, Guasch G
Eur J Dermatol
. 2013 Apr;
PMID: 23587865
The TGF-β superfamily is involved in embryonic development and regulation of many cellular processes. Importantly, these signaling molecules have been increasingly revealed to play a crucial role in exocrine gland...
6.
McNairn A, Doucet Y, Demaude J, Brusadelli M, Gordon C, Uribe-Rivera A, et al.
BMC Dermatol
. 2013 Jan;
13:2.
PMID: 23343495
Background: Sebaceous glands are components of the skin essential for its normal lubrication by the production of sebum. This contributes to skin health and more importantly is crucial for the...
7.
Wallace M, Pfefferle A, Shen L, McNairn A, Cerami E, Fallon B, et al.
Genetics
. 2012 Aug;
192(2):385-96.
PMID: 22851646
Identifying genomic alterations driving breast cancer is complicated by tumor diversity and genetic heterogeneity. Relevant mouse models are powerful for untangling this problem because such heterogeneity can be controlled. Inbred...
8.
McNairn A, Guasch G
Eur J Dermatol
. 2011 Jun;
21 Suppl 2:21-8.
PMID: 21628126
Transition zones (TZs) are regions in the body where two different types of epithelial tissue meet resulting in the appearance of a distinct abrupt transition. These TZs are found in...
9.
Lu S, Goering M, Gard S, Xiong B, McNairn A, Jaspersen S, et al.
Cell Cycle
. 2010 Aug;
9(16):3315-27.
PMID: 20703090
The cohesin network has an essential role in chromosome segregation, but also plays a role in DNA damage repair. Eco1 is an acetyltransferase that targets subunits of the cohesin complex...
10.
Gard S, Light W, Xiong B, Bose T, McNairn A, Harris B, et al.
J Cell Biol
. 2009 Dec;
187(4):455-62.
PMID: 19948494
In Saccharomyces cerevisiae, chromatin is spatially organized within the nucleus with centromeres clustering near the spindle pole body, telomeres clustering into foci at the nuclear periphery, ribosomal DNA repeats localizing...