Adrian C Lo
Overview
Explore the profile of Adrian C Lo including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
652
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Recent Articles
1.
Mercaldo V, Vidimova B, Gastaldo D, Fernandez E, Lo A, Cencelli G, et al.
Neuron
. 2023 Mar;
111(11):1760-1775.e8.
PMID: 36996810
The proteome of glutamatergic synapses is diverse across the mammalian brain and involved in neurodevelopmental disorders (NDDs). Among those is fragile X syndrome (FXS), an NDD caused by the absence...
2.
Mariano V, Kanellopoulos A, Aiello G, Lo A, Legius E, Achsel T, et al.
Nat Commun
. 2023 Feb;
14(1):763.
PMID: 36808152
Sleep behavior is conserved throughout evolution, and sleep disturbances are a frequent comorbidity of neuropsychiatric disorders. However, the molecular basis underlying sleep dysfunctions in neurological diseases remains elusive. Using a...
3.
Lo A, Rajan N, Gastaldo D, Telley L, Hilal M, Buzzi A, et al.
EMBO Rep
. 2021 Mar;
22(4):e51404.
PMID: 33779029
Status epilepticus (SE) is a condition in which seizures are not self-terminating and thereby pose a serious threat to the patient's life. The molecular mechanisms underlying SE are likely heterogeneous...
4.
Dominguez-Iturza N, Lo A, Shah D, Armendariz M, Vannelli A, Mercaldo V, et al.
Nat Commun
. 2019 Aug;
10(1):3454.
PMID: 31371726
Copy-number variants of the CYFIP1 gene in humans have been linked to autism spectrum disorders (ASD) and schizophrenia (SCZ), two neuropsychiatric disorders characterized by defects in brain connectivity. Here, we...
5.
Briz V, Restivo L, Pasciuto E, Juczewski K, Mercaldo V, Lo A, et al.
Nat Commun
. 2017 Aug;
8(1):293.
PMID: 28819097
The brain cytoplasmic (BC1) RNA is a non-coding RNA (ncRNA) involved in neuronal translational control. Absence of BC1 is associated with altered glutamatergic transmission and maladaptive behavior. Here, we show...
6.
Latif-Hernandez A, Shah D, Ahmed T, Lo A, Callaerts-Vegh Z, Van Der Linden A, et al.
Sci Rep
. 2016 Nov;
6:36489.
PMID: 27819338
Intracerebral injection of the excitotoxic, endogenous tryptophan metabolite, quinolinic acid (QA), constitutes a chemical model of neurodegenerative brain disease. Complementary techniques were combined to examine the consequences of QA injection...
7.
Verreet T, Rangarajan J, Quintens R, Verslegers M, Lo A, Govaerts K, et al.
Front Behav Neurosci
. 2016 May;
10:83.
PMID: 27199692
Prenatal irradiation is known to perturb brain development. Epidemiological studies revealed that radiation exposure during weeks 8-15 of pregnancy was associated with an increased occurrence of mental disability and microcephaly....
8.
Huang Y, Skwarek-Maruszewska A, Horre K, Vandewyer E, Wolfs L, Snellinx A, et al.
Sci Transl Med
. 2015 Oct;
7(309):309ra164.
PMID: 26468326
The orphan G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR) GPR3 regulates activity of the γ-secretase complex in the absence of an effect on Notch proteolysis, providing a potential therapeutic...
9.
Dionisio P, Amaral J, Ribeiro M, Lo A, DHooge R, Rodrigues C
Neurobiol Aging
. 2014 Dec;
36(1):228-40.
PMID: 25443293
Alzheimer's disease (AD) is a neurodegenerative disorder hallmarked by the accumulation of extracellular amyloid-β (Aβ) peptide and intraneuronal hyperphosphorylated tau, as well as chronic neuroinflammation. Tauroursodeoxycholic acid (TUDCA) is an...
10.
Lo A, De Maeyer J, Vermaercke B, Callaerts-Vegh Z, Schuurkes J, DHooge R
Neuropharmacology
. 2014 May;
85:178-89.
PMID: 24863046
5-HT4 receptors (5-HT4R) are suggested to affect learning and memory processes. Earlier studies have shown that animals treated with 5-HT4R agonists, often with limited selectivity, show improved learning and memory...